A decade of progress in juvenile idiopathic arthritis treatments and outcomes in Canada: results from ReACCh-Out and the CAPRI registry.

Autor:	Nguyen K; Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada., Barsalou J; Department of Pediatrics, Université de Montréal, Montréal, QC, Canada., Basodan D; Department of Pediatrics, University of Alberta, Edmonton, AB, Canada., Batthish M; Department of Pediatrics, McMaster University, Hamilton, ON, Canada., Benseler SM; Department of Pediatrics, University of Calgary, Calgary, AB, Canada., Berard RA; Department of Pediatrics, Western University, London, ON, Canada., Blanchette N; Health Sciences North, Sudbury, ON, Canada., Boire G; Department of Pediatrics, Université de Sherbrooke, Sherbrooke, QC, Canada., Bolaria R; Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada., Bruns A; Department of Pediatrics, Université de Sherbrooke, Sherbrooke, QC, Canada., Cabral DA; Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada., Cameron B; Department of Pediatrics, University of Toronto, Toronto, ON, Canada., Campillo S; Department of Pediatrics, McGill University, Montreal, QC, Canada., Cellucci T; Department of Pediatrics, McMaster University, Hamilton, ON, Canada., Chan M; Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada., Chédeville G; Department of Pediatrics, McGill University, Montreal, QC, Canada., Chetaille AL; Department of Pediatrics, CHU de Québec-Université Laval, Québec, Canada., Chhabra A; Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada., Couture J; Department of Pediatrics, Université de Montréal, Montréal, QC, Canada., Dancey P; Department of Pediatrics, Memorial University, St. John's, NL, Canada., De Bruycker JJ; Department of Pediatrics, Université de Montréal, Montréal, QC, Canada., Demirkaya E; Department of Pediatrics, Western University, London, ON, Canada., Dhalla M; Department of Pediatrics, University of Calgary, Calgary, AB, Canada., Duffy CM; Department of Pediatrics, University of Ottawa, Ottawa, ON, Canada., Feldman BM; Department of Pediatrics, University of Toronto, Toronto, ON, Canada., Feldman DE; Department of Pediatrics, Université de Montréal, Montréal, QC, Canada., Gerschman T; Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada., Haddad E; Department of Pediatrics, Université de Montréal, Montréal, QC, Canada., Heale L; Department of Pediatrics, McMaster University, Hamilton, ON, Canada., Herrington J; Department of Pediatrics, McMaster University, Hamilton, ON, Canada., Houghton K; Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada., Huber AM; Department of Pediatrics, Dalhousie University, Halifax, NS, Canada., Human A; Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada., Johnson N; Department of Pediatrics, University of Calgary, Calgary, AB, Canada., Jurencak R; Department of Pediatrics, University of Ottawa, Ottawa, ON, Canada., Lang B; Department of Pediatrics, Dalhousie University, Halifax, NS, Canada., Larché M; Department of Pediatrics, McMaster University, Hamilton, ON, Canada., Laxer RM; Department of Pediatrics, University of Toronto, Toronto, ON, Canada., LeBlanc CM; Department of Pediatrics, McGill University, Montreal, QC, Canada., Lee JJY; Department of Pediatrics, University of Toronto, Toronto, ON, Canada., Levy DM; Department of Pediatrics, University of Toronto, Toronto, ON, Canada., Lim L; Department of Pediatrics, University of Alberta, Edmonton, AB, Canada., Lim LSH; Department of Pediatrics, University of Manitoba, Winnipeg, MB, Canada., Luca N; Department of Pediatrics, University of Ottawa, Ottawa, ON, Canada., McGrath T; Department of Pediatrics, University of Alberta, Edmonton, AB, Canada., McMillan T; Department of Pediatrics, University of Manitoba, Winnipeg, MB, Canada., Miettunen PM; Department of Pediatrics, University of Calgary, Calgary, AB, Canada., Morishita KA; Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada., Ng HY; Department of Pediatrics, University of Saskatchewan, Saskatoon, SK, Canada., Oen K; Department of Pediatrics, University of Manitoba, Winnipeg, MB, Canada., Park J; Department of Pediatrics, Western University, London, ON, Canada., Petty RE; Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada., Proulx-Gauthier JP; Department of Pediatrics, CHU de Québec-Université Laval, Québec, Canada., Ramsey S; Department of Pediatrics, Dalhousie University, Halifax, NS, Canada., Roth J; Department of Pediatrics, University of Ottawa, Ottawa, ON, Canada., Rosenberg AM; Department of Pediatrics, University of Saskatchewan, Saskatoon, SK, Canada., Rozenblyum E; Department of Pediatrics, University of Toronto, Toronto, ON, Canada., Rumsey DG; Department of Pediatrics, University of Alberta, Edmonton, AB, Canada., Schmeling H; Department of Pediatrics, University of Calgary, Calgary, AB, Canada., Schneider R; Department of Pediatrics, University of Toronto, Toronto, ON, Canada., Scuccimarri R; Department of Pediatrics, McGill University, Montreal, QC, Canada., Shiff NJ; Department of Pediatrics, University of Saskatchewan, Saskatoon, SK, Canada., Silverman E; Department of Pediatrics, University of Toronto, Toronto, ON, Canada., Soon G; Health Sciences North, Sudbury, ON, Canada.; North York General Hospital, North York, Toronto, ON, Canada., Spiegel L; Department of Pediatrics, University of Toronto, Toronto, ON, Canada., Stringer E; Department of Pediatrics, Dalhousie University, Halifax, NS, Canada., Tam H; Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada., Tse SM; Department of Pediatrics, University of Toronto, Toronto, ON, Canada., Tucker LB; Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada., Turvey S; Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada., Twilt M; Department of Pediatrics, University of Calgary, Calgary, AB, Canada., Duffy KW; Department of Pediatrics, University of Ottawa, Ottawa, ON, Canada., Yeung RSM; Department of Pediatrics, University of Toronto, Toronto, ON, Canada., Guzman J; Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
Jazyk:	angličtina
Zdroj:	Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2024 Sep 01; Vol. 63 (SI2), pp. SI173-SI179.
DOI:	10.1093/rheumatology/kead560
Abstrakt:	Objective: To assess changes in juvenile idiopathic arthritis (JIA) treatments and outcomes in Canada, comparing 2005-2010 and 2017-2021 inception cohorts. Methods: Patients enrolled within three months of diagnosis in the Research in Arthritis in Canadian Children Emphasizing Outcomes (ReACCh-Out) and the Canadian Alliance of Pediatric Rheumatology Investigators Registry (CAPRI) cohorts were included. Cumulative incidences of drug starts and outcome attainment within 70 weeks of diagnosis were compared with Kaplan-Meier survival analysis and multivariable Cox regression. Results: The 2005-2010 and 2017-2021 cohorts included 1128 and 721 patients, respectively. JIA category distribution and baseline clinical juvenile idiopathic arthritis disease activity (cJADAS10) scores at enrolment were comparable. By 70 weeks, 6% of patients (95% CI 5, 7) in the 2005-2010 and 26% (23, 30) in the 2017-2021 cohort had started a biologic DMARD (bDMARD), and 43% (40, 47) and 60% (56, 64) had started a conventional DMARD (cDMARD), respectively. Outcome attainment was 64% (61, 67) and 83% (80, 86) for inactive disease (Wallace criteria), 69% (66, 72) and 84% (81, 87) for minimally active disease (cJADAS10 criteria), 57% (54, 61) and 63% (59, 68) for pain control (<1/10), and 52% (47, 56) and 54% (48, 60) for good health-related quality of life (≥9/10). Conclusion: Although baseline disease characteristics were comparable in the 2005-2010 and 2017-2021 cohorts, cDMARD and bDMARD use increased with a concurrent increase in minimally active and inactive disease. Improvements in parent and patient-reported outcomes were smaller than improvements in disease activity. (© The Author(s) 2023. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
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