Kinetics of severe dengue virus infection and development of gut pathology in mice.

Autor:	Pliego Zamora A; School of Chemistry and Molecular Biosciences, The University of Queensland , St Lucia, Queensland, Australia., Kim J; School of Chemistry and Molecular Biosciences, The University of Queensland , St Lucia, Queensland, Australia., Vajjhala PR; School of Chemistry and Molecular Biosciences, The University of Queensland , St Lucia, Queensland, Australia., Thygesen SJ; School of Chemistry and Molecular Biosciences, The University of Queensland , St Lucia, Queensland, Australia., Watterson D; School of Chemistry and Molecular Biosciences, The University of Queensland , St Lucia, Queensland, Australia.; Australian Infectious Diseases Research Centre, The University of Queensland , St Lucia, Queensland, Australia., Modhiran N; School of Chemistry and Molecular Biosciences, The University of Queensland , St Lucia, Queensland, Australia., Bielefeldt-Ohmann H; School of Chemistry and Molecular Biosciences, The University of Queensland , St Lucia, Queensland, Australia.; Australian Infectious Diseases Research Centre, The University of Queensland , St Lucia, Queensland, Australia., Stacey KJ; School of Chemistry and Molecular Biosciences, The University of Queensland , St Lucia, Queensland, Australia.; Australian Infectious Diseases Research Centre, The University of Queensland , St Lucia, Queensland, Australia.
Jazyk:	angličtina
Zdroj:	Journal of virology [J Virol] 2023 Nov 30; Vol. 97 (11), pp. e0125123. Date of Electronic Publication: 2023 Oct 18.
DOI:	10.1128/jvi.01251-23
Abstrakt:	Importance: Dengue virus, an arbovirus, causes an estimated 100 million symptomatic infections annually and is an increasing threat as the mosquito range expands with climate change. Dengue epidemics are a substantial strain on local economies and health infrastructure, and an understanding of what drives severe disease may enable treatments to help reduce hospitalizations. Factors exacerbating dengue disease are debated, but gut-related symptoms are much more frequent in severe than mild cases. Using mouse models of dengue infection, we have shown that inflammation and damage are earlier and more severe in the gut than in other tissues. Additionally, we observed impairment of the gut mucus layer and propose that breakdown of the barrier function exacerbates inflammation and promotes severe dengue disease. This idea is supported by recent data from human patients showing elevated bacteria-derived molecules in dengue patient serum. Therapies aiming to maintain gut integrity may help to abrogate severe dengue disease. Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
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