Genomic, transcriptomic, and phenotypic differences among archetype Shigella flexneri strains of serotypes 2a, 3a, and 6.

Autor:	Gabor CE; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA., Hazen TH; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA., Delaine-Elias BC; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA., Rasko DA; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.; Center for Pathogen Research, University of Maryland School of Medicine, Baltimore, Maryland, USA., Barry EM; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Jazyk:	angličtina
Zdroj:	MSphere [mSphere] 2023 Dec 20; Vol. 8 (6), pp. e0040823. Date of Electronic Publication: 2023 Oct 13.
DOI:	10.1128/msphere.00408-23
Abstrakt:	Importance: Given the genomic diversity between S. flexneri serotypes and the paucity of data to support serotype-specific phenotypic differences, we applied in silico and in vitro functional analyses of archetype strains of 2457T ( Sf 2a), J17B ( Sf 3a), and CH060 ( Sf 6). These archetype strains represent the three leading S. flexneri serotypes recommended for inclusion in multivalent vaccines. Characterizing the genomic and phenotypic variation among these clinically prevalent serotypes is an important step toward understanding serotype-specific host-pathogen interactions to optimize the efficacy of multivalent vaccines and therapeutics. This study underpins the importance for further large-scale serotype-targeted analyses. Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
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