Sustain release of dexamethasone from polyvinyl alcohol microparticle produced via coaxial microfluidic system.

Autor: Abdi Majareh M; Department of Microbiology, Karaj Branch, Islamic Azad University, Karaj, Iran., Davachi SM; Department of Biology and Chemistry, Texas A&M International University, 78041, Laredo, TX, USA., Tavakoli Moghaddam Y; Skull Base Research Center, The Five Senses Institute, School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran., Khanmohammadi M; Skull Base Research Center, The Five Senses Institute, School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran. Mehdi.khanmohammadi84@gmail.com.; Biomaterials Group, Materials Design Division, Faculty of Materials Science and Engineering, Warsaw University of Technology, Warsaw, Poland. Mehdi.khanmohammadi84@gmail.com.
Jazyk: angličtina
Zdroj: BMC research notes [BMC Res Notes] 2023 Oct 12; Vol. 16 (1), pp. 268. Date of Electronic Publication: 2023 Oct 12.
DOI: 10.1186/s13104-023-06544-3
Abstrakt: Objective: Polyvinyl alcohol (PVA) as a synthetic biopolymer has unique physicochemical properties to achieve an efficient drug carrier. In this study phenol-substituted polyvinyl alcohol (PVAPh) microparticle was made through a microfluidic system and peroxidase-mediated reaction in the presence of hydrogen peroxide and in following dexamethasone (Dex) release characteristics from this vehicle were elaborated for sustained drug delivery applications.
Results: PVAPh was synthesized by esterification and amidation reactions respectively. Then, the synthesized PVAPh solution containing peroxidase and Dex flowed within the inner channel of the coaxial microfluidic device while liquid paraffin saturated with H 2 O 2 flowed from the outer channel. The monodisperse microparticles were produced in a spherical shape with an average diameter of 160 μm. The Dex was successfully encapsulated in PVAPh MP and its sustained release profile was maintained for up to 7 days. It was found that exposure of Dex-loaded PVAPh MPs to subcultured mouse embryonic fibroblast 10T1/2 cells had no deleterious effects on cell viability, morphology and growth rate. Moreover, the sustained release of Dex and the high mechanical durability of PVAPh MPs suggest an excellent prospect for the synthesized PVAPh and the developed method as a biocompatible carrier required for drug delivery and regenerative medicine.
(© 2023. BioMed Central Ltd., part of Springer Nature.)
Databáze: MEDLINE
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