New insights at the interface between leprosy and immune-mediated rheumatic diseases.
| Autor: | Cruz VA; Federal University of Goiás, Goiás, Brazil., de Albuquerque CP; Department of Rheumatology, University of Brasilia, Brasilia, Brazil., Guimarães MFBR; Department of Rheumatology, Federal University of Minas Gerais, Belo Horizonte, Brazil., Dionello CDF; Department of Rheumatology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Ribeiro SLE; Department of Rheumatology, Federal University of Amazonas, Manaus, Brazil., de Souza VA; Department of Rheumatology, Federal University of Juiz de Fora, Juiz de Fora, Brazil., Gomes CM; Department of Dermatology, University of Brasilia, Brasilia, Brazil., da Mota LMH; Department of Rheumatology, University of Brasilia, Brasilia, Brazil. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in medicine [Front Med (Lausanne)] 2023 Sep 25; Vol. 10, pp. 1239775. Date of Electronic Publication: 2023 Sep 25 (Print Publication: 2023). |
| DOI: | 10.3389/fmed.2023.1239775 |
| Abstrakt: | Leprosy is an infectious and contagious disease of slow evolution, triggered by Mycobacterium leprae . Arthritis is its third most common manifestation, after cutaneous and peripheral nerve involvement. Since musculoskeletal symptoms may be the initial presentation of the disease, it is important for health professionals to recognize its rheumatic manifestations for early diagnosis and appropriate treatment, especially in endemic areas. In addition, cases of leprosy have increased globally, notably in patients undergoing treatment with TNF-α blockers and due to the increase in migration and travel of people from developing countries to developed countries. This review proposes to discuss the main scenarios of mimicry of different rheumatic diseases by leprosy, as well as the role of immunosuppressive drugs used in rheumatology practice in the treatment of reactional states and in the risk of developing the infection. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Cruz, Albuquerque, Guimarães, Dionello, Ribeiro, Souza, Gomes and Mota.) |
| Databáze: | MEDLINE |
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