The use of a 4.7 mg deslorelin slow release implant in male dogs in the field.

Autor:	Vasetska A; Reproductive Unit - Clinic for Small Animals, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany., Körber H; Reproductive Unit - Clinic for Small Animals, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany., Pilgram C; Reproductive Unit - Clinic for Small Animals, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany., Schuler G; Veterinary Clinic for Reproductive Medicine and Neonatology, Faculty of Veterinary Medicine, Justus-Liebig-University Giessen, Germany., Aslan S; Department of Obstetrics and Gynaecology - Faculty of Veterinary Medicine, Near East University, Nicosia, Cyprus., Saral G; Department of Obstetrics and Gynaecology - Faculty of Veterinary Medicine, Ondokuz Mayıs University, Samsun, Turkey., Binli F; Department of Obstetrics and Gynaecology - Faculty of Veterinary Medicine, Ondokuz Mayıs University, Samsun, Turkey., Akal E; Department of Reproduction and Artificial Insemination - Faculty of Veterinary Medicine, Ondokuz Mayıs University, Samsun, Turkey., Selcuk M; Department of Reproduction and Artificial Insemination - Faculty of Veterinary Medicine, Ondokuz Mayıs University, Samsun, Turkey., Ay S; Department of Obstetrics and Gynaecology - Faculty of Veterinary Medicine, Ondokuz Mayıs University, Samsun, Turkey., Findik M; Department of Obstetrics and Gynaecology - Faculty of Veterinary Medicine, Ondokuz Mayıs University, Samsun, Turkey., Fontaine CS; Companion Animal Medical Department, Virbac group, Carros, France., Goericke-Pesch S; Reproductive Unit - Clinic for Small Animals, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany.
Jazyk:	angličtina
Zdroj:	Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere [Tierarztl Prax Ausg K Kleintiere Heimtiere] 2023 Aug; Vol. 51 (4), pp. 231-241. Date of Electronic Publication: 2023 Oct 11.
DOI:	10.1055/a-2142-4194
Abstrakt:	Objective: Slow-release GnRH agonist implants (SRI) are used for reversible medical downregulation of testicular function in male dogs as an alternative to surgery. The 4.7 mg deslorelin SRI should reduce testosterone after 6-8 weeks and induce castration-like effects for 6 months (mon). However, some individual variation is described in the field in regard to onset and duration of effect. For this reason, we aimed to study the effects of the 4.7 mg deslorelin SRI in a larger cohort. Material and Methods: In total 50 intact, healthy male dogs (12-48 months, mon; 9-40 kg) were treated with a 4.7 mg deslorelin SRI into the umbilical area (TG, n=45) or served as untreated controls (CG, n=5). CG dogs were surgically castrated after measurement of testicular dimensions and blood sampling for testosterone. In TG, SRIs remained for 5 mon in place and subsequently 3-7 male dogs were surgically castrated at removal (week, W 0) or 1, 2, 3, 4, 5, 6, 7, 8 or 10 weeks later. Examination parameters were testicular dimensions (before treatment, at 4, 8, 12 W, 5 mon, weekly until castration), testosterone (before treatment, at 8 W, 5 mon, castration) and testicular histology (castration). Results: Whereas examination parameters did not differ between CG and TG before treatment, testicular volume and testosterone was significantly reduced at all time points during treatment. In all but 3 (8 W) and 2 male dogs (5 mon) testosterone was basal during treatment before removal, whereas the parameters were significantly reduced compared to pre-treatment in the respective dogs. After implant removal, testosterone and testicular volumes increased. However, different to earlier studies, the "restart" was more variable with individual basal testosterone until W7, but also physiological testosterone concentrations in W2. Similarly, histological testicular findings at castration were quite variable: besides an arrest on spermatogonia and spermatocytes, elongated spermatids with normal spermatogenesis were found in individual dogs. Conclusion: Our study confirms the efficacy of the deslorelin SRI, but also individual variation especially regarding reversibility of effects on endocrine and germinative testicular function. Clinical Relevance: Deslorelin SRIs offer a suitable alternative to surgical castration with individual variation to be considered when used in clinical practice. Competing Interests: SGP lectured for Virbac and did contract-based research for Virbac. Besides, the project was funded by Virbac and Minitube. The funders, however, had no influence on the results. (Thieme. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu