Adjusting for Berkson error in exposure in ordinary and conditional logistic regression and in Poisson regression.

Autor: Oraby T; School of Mathematical and Statistical Sciences, University of Texas Rio Grande Valley, Edinburg, TX, USA. tamer.oraby@utrgv.edu., Chakraborty S; School of Mathematical and Statistical Sciences, University of Texas Rio Grande Valley, Edinburg, TX, USA., Sivaganesan S; Department of Mathematical Sciences, University of Cincinnati, Cincinnati, OH, USA., Kincl L; College of Health, Oregon State University, Corvallis, OR, USA., Richardson L; CRCHUM, Centre de Recherche Hospitalier de L'université de Montréal, Montreal, QC, Canada., McBride M; BC Cancer Agency, Vancouver, BC, Canada., Siemiatycki J; CRCHUM, Centre de Recherche Hospitalier de L'université de Montréal, Montreal, QC, Canada., Cardis E; Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.; Pompeu Fabra University, Barcelona, Spain.; Spanish Consortium for Research and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain., Krewski D; McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, ON, Canada.; Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Canada.; Risk Sciences International, Ottawa, Canada.
Jazyk: angličtina
Zdroj: BMC medical research methodology [BMC Med Res Methodol] 2023 Oct 10; Vol. 23 (1), pp. 225. Date of Electronic Publication: 2023 Oct 10.
DOI: 10.1186/s12874-023-02044-x
Abstrakt: Background: INTEROCC is a seven-country cohort study of occupational exposures and brain cancer risk, including occupational exposure to electromagnetic fields (EMF). In the absence of data on individual exposures, a Job Exposure Matrix (JEM) may be used to construct likely exposure scenarios in occupational settings. This tool was constructed using statistical summaries of exposure to EMF for various occupational categories for a comparable group of workers.
Methods: In this study, we use the Canadian data from INTEROCC to determine the best EMF exposure surrogate/estimate from three appropriately chosen surrogates from the JEM, along with a fourth surrogate based on Berkson error adjustments obtained via numerical approximation of the likelihood function. In this article, we examine the case in which exposures are gamma-distributed for each occupation in the JEM, as an alternative to the log-normal exposure distribution considered in a previous study conducted by our research team. We also study using those surrogates and the Berkson error adjustment in Poisson regression and conditional logistic regression.
Results: Simulations show that the introduced methods of Berkson error adjustment for non-stratified analyses provide accurate estimates of the risk of developing tumors in case of gamma exposure model. Alternatively, and under some technical assumptions, the arithmetic mean is the best surrogate when a gamma-distribution is used as an exposure model. Simulations also show that none of the present methods could provide an accurate estimate of the risk in case of stratified analyses.
Conclusion: While our previous study found the geometric mean to be the best exposure surrogate, the present study suggests that the best surrogate is dependent on the exposure model; the arithmetic means in case of gamma-exposure model and the geometric means in case of log-normal exposure model. However, we could present a better method of Berkson error adjustment for each of the two exposure models. Our results provide useful guidance on the application of JEMs for occupational exposure assessments, with adjustment for Berkson error.
(© 2023. BioMed Central Ltd., part of Springer Nature.)
Databáze: MEDLINE
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