Advances in chitosan-based hydrogels for pharmaceutical and biomedical applications: A comprehensive review.

Autor: Almajidi YQ; Department of Pharmacy, Baghdad College of Medical Sciences, Baghdad, Iraq., Gupta J; Institute of Pharmaceutical Research, GLA University, Mathura Pin Code 281406, U.P., India., Sheri FS; College of Dentistry, National University of Science and Technology, Dhi Qar, Iraq., Zabibah RS; Medical Laboratory Technology Department, College of Medical Technology, The Islamic University, Najaf, Iraq., Faisal A; Department of Pharmacy, Al-Noor University College, Nineveh, Iraq., Ruzibayev A; Department of Food Products Technology, Tashkent Institute of Chemical Technology, Navoi street 32, 100011 Tashkent City, Uzbekistan., Adil M; Pharmacy College, Al-Farahidi University, Baghdad, Iraq., Saadh MJ; Faculty of Pharmacy, Middle East University, Amman 11831, Jordan., Jawad MJ; Department of Pharmacy, Al-Zahrawi University College, Karbala, Iraq., Alsaikhan F; College of Pharmacy, Prince Sattam Bin Abdulaziz University, Alkharj, Saudi Arabia; School of Pharmacy, Ibn Sina National College for Medical Studies, Jeddah, Saudi Arabia. Electronic address: fsaikhan@hotmail.com., Narmani A; Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran. Electronic address: Asgharnarmani@yahoo.com., Farhood B; Department of Medical Physics and Radiology, Faculty of Paramedical Sciences, Kashan University of Medical Sciences, Kashan, Iran. Electronic address: farhood-b@kaums.ac.ir.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2023 Dec 31; Vol. 253 (Pt 6), pp. 127278. Date of Electronic Publication: 2023 Oct 06.
DOI: 10.1016/j.ijbiomac.2023.127278
Abstrakt: The treatment of diseases, such as cancer, is one of the most significant issues correlated with human beings health. Hydrogels (HGs) prepared from biocompatible and biodegradable materials, especially biopolymers, have been effectively employed for the sort of pharmaceutical and biomedical applications, including drug delivery systems, biosensors, and tissue engineering. Chitosan (CS), one of the most abundant bio-polysaccharide derived from chitin, is an efficient biomaterial in the prognosis, diagnosis, and treatment of diseases. CS-based HGs possess some potential advantages, like high values of bioactive encapsulation, efficient drug delivery to a target site, sustained drug release, good biocompatibility and biodegradability, high serum stability, non-immunogenicity, etc., which made them practical and useful for pharmaceutical and biomedical applications. In this review, we summarize recent achievements and advances associated with CS-based HGs for drug delivery, regenerative medicine, disease detection and therapy.
Competing Interests: Declaration of competing interest None.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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