The Impact in Intestines and Microbiota in BALB/c Mice Through Consumption of Milk Fermented by Potentially Probiotic Lacticaseibacillus casei SJRP38 and Limosilactobacillus fermentum SJRP43.

Autor: de Souza BMS; Department of Technology and Inspection of Products of Animal Origin, UFMG - Federal University of Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil., Guerra LHA; Department of Biology, Institute of Biosciences, Languages and Exact Sciences, UNESP - Sao Paulo State University, São José do Rio Preto, SP, 15054-000, Brazil., Varallo GR; Araraquara City Hall, Araraquara, SP, 14801-901, Brazil., Taboga SR; Department of Biology, Institute of Biosciences, Languages and Exact Sciences, UNESP - Sao Paulo State University, São José do Rio Preto, SP, 15054-000, Brazil., Penna ALB; Department of Food Engineering and Technology, Institute of Biosciences, Languages and Exact Sciences, UNESP - Sao Paulo State University, São José do Rio Preto, SP, 15054-000, Brazil. ana.lb.penna@unesp.br.
Jazyk: angličtina
Zdroj: Probiotics and antimicrobial proteins [Probiotics Antimicrob Proteins] 2023 Oct 05. Date of Electronic Publication: 2023 Oct 05.
DOI: 10.1007/s12602-023-10158-3
Abstrakt: The present study aimed to evaluate the effect of consumption of milk fermented by Lacticaseibacillus (Lc.) casei SJRP38 and Limosilactobacillus (Lm.) fermentum SJRP43 on bacterial translocation, stool analysis, and intestinal morphology of healthy BALB/c mice. Potentially probiotic lactic acid bacteria, Lc. casei SJRP38, and Lm. fermentum SJRP43 were evaluated and analyzed for translocation, fecal analysis, and intestinal morphology of four groups of mice: water control (WC), milk control (MC), milk fermented by Lc. casei SJRP38 (FMLC), and milk fermented by Lm. fermentum SJRP43 (FMLF), in co-culture with Streptococcus thermophilus ST080. The results of the animal assay indicate that the population of Lactobacilli and Bidobacterium sp. in the gastrointestinal tract of BALB/c mice was greater than 6.0 log 10 CFU/g, and there was no evidence of bacteremia due to the low incidence of bacterial translocation. Ingesting fermented milk containing Lc. casei SJRP38 and Lm. fermentum SJRP43 was found to promote a healthier microbiota, as it led to a reduction in Clostridium sp. and an increase in Lactobacilli and Bifidobacterium sp. in feces. Furthermore, the dairy treatments (MC, FMLC, and FMLF) resulted in taller intestinal villi and an increase in the frequency of goblet cells in the intestines. Overall, the consumption of fermented milk containing Lc. casei SJRP38 and Lm. fermentum SJRP43 strains was deemed safe and demonstrated beneficial effects on the intestines of BALB/c mice.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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