Genetics of vegetarianism: A genome-wide association study.

Autor: Yaseen NR; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States of America., Barnes CLK; Fios Genomics, Edinburgh, United Kingdom., Sun L; Department of Psychiatry, School of Medicine, Washington University in St. Louis, St. Louis, MO, United States of America., Takeda A; Retired, St. Louis, MO, United States of America., Rice JP; Department of Psychiatry, School of Medicine, Washington University in St. Louis, St. Louis, MO, United States of America.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2023 Oct 04; Vol. 18 (10), pp. e0291305. Date of Electronic Publication: 2023 Oct 04 (Print Publication: 2023).
DOI: 10.1371/journal.pone.0291305
Abstrakt: A substantial body of evidence points to the heritability of dietary preferences. While vegetarianism has been practiced for millennia in various societies, its practitioners remain a small minority of people worldwide, and the role of genetics in choosing a vegetarian diet is not well understood. Dietary choices involve an interplay between the physiologic effects of dietary items, their metabolism, and taste perception, all of which are strongly influenced by genetics. In this study, we used a genome-wide association study (GWAS) to identify loci associated with strict vegetarianism in UK Biobank participants. Comparing 5,324 strict vegetarians to 329,455 controls, we identified one SNP on chromosome 18 that is associated with vegetarianism at the genome-wide significant level (rs72884519, β = -0.11, P = 4.997 x 10-8), and an additional 201 suggestively significant variants. Four genes are associated with rs72884519: TMEM241, RIOK3, NPC1, and RMC1. Using the Functional Mapping and Annotation (FUMA) platform and the Multi-marker Analysis of GenoMic Annotation (MAGMA) tool, we identified 34 genes with a possible role in vegetarianism, 3 of which are GWAS-significant based on gene-level analysis: RIOK3, RMC1, and NPC1. Several of the genes associated with vegetarianism, including TMEM241, NPC1, and RMC1, have important functions in lipid metabolism and brain function, raising the possibility that differences in lipid metabolism and their effects on the brain may underlie the ability to subsist on a vegetarian diet. These results support a role for genetics in choosing a vegetarian diet and open the door to future studies aimed at further elucidating the physiologic pathways involved in vegetarianism.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2023 Yaseen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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