Prospective validation of an equation based on plasma cystatin C for monitoring the glomerular filtration rate in children treated with cisplatin or ifosfamide for cancer.

Autor: Lambert M; CRCT, Université de Toulouse, Inserm, Toulouse, France.; Oncopole Claudius-Regaud, IUCT-Oncopole, 1, Avenue Irène Joliot-Curie, 31059, Toulouse Cedex, France., Alonso M; Unité de Radiopharmacie, CHU de Toulouse-Purpan, Toulouse, France., Munzer C; Unité de Recherche Clinique Pédiatrique, Hôpital des Enfants, CHU Toulouse, Toulouse, France.; Unité d'Hémato-Oncologie, Hôpital des Enfants, CHU Toulouse, Toulouse, France., Zimoch MC; Oncopole Claudius-Regaud, IUCT-Oncopole, 1, Avenue Irène Joliot-Curie, 31059, Toulouse Cedex, France., Malard L; Oncopole Claudius-Regaud, IUCT-Oncopole, 1, Avenue Irène Joliot-Curie, 31059, Toulouse Cedex, France., Gambart M; Unité d'Hémato-Oncologie, Hôpital des Enfants, CHU Toulouse, Toulouse, France., Castex MP; Unité d'Hémato-Oncologie, Hôpital des Enfants, CHU Toulouse, Toulouse, France., Martins C; Unité de Recherche Clinique Pédiatrique, Hôpital des Enfants, CHU Toulouse, Toulouse, France., Pasquet M; Unité d'Hémato-Oncologie, Hôpital des Enfants, CHU Toulouse, Toulouse, France.; CRCT, Equipe 16, IUCT-Oncopole, Toulouse, France., Chatelut E; CRCT, Université de Toulouse, Inserm, Toulouse, France. Chatelut.etienne@iuct-oncopole.fr.; Oncopole Claudius-Regaud, IUCT-Oncopole, 1, Avenue Irène Joliot-Curie, 31059, Toulouse Cedex, France. Chatelut.etienne@iuct-oncopole.fr.
Jazyk: angličtina
Zdroj: Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 2024 Apr; Vol. 93 (4), pp. 393-395. Date of Electronic Publication: 2023 Oct 03.
DOI: 10.1007/s00280-023-04597-6
Abstrakt: We recently proposed an equation to estimate the glomerular filtration rate (GFR) in children with cancer based on plasma cystatin C and serum creatinine levels together with body weight (the "CysPed equation"). The current clinical study reports a prospective evaluation of this equation in 18 children treated by nephrotoxic chemotherapy. The CysPed equation resulted in less bias and greater precision compared to two equations previously proposed equations by Schwartz, with or without plasma cystatin C. Moreover, the decrease in GFR due to chemotherapy was clearly identified by the CysPed equation. This equation may be used to monitor the renal function in childhood cancer units.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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