Bronchopulmonary penetration of isavuconazole in lung transplant recipients.

Autor:	Caballero-Bermejo AF; Clinical Pharmacology Department, Hospital Universitario Puerta de Hierro-Majadahonda, Instituto de Investigación Sanitaria Puerta de Hierro-Segovia de Arana , Majadahonda, Madrid, Spain.; Internal Medicine Department, Mater Misericordiae University Hospital , Dublin, Ireland., Darnaude-Ximénez I; Clinical Pharmacology Department, Hospital Universitario Puerta de Hierro-Majadahonda, Instituto de Investigación Sanitaria Puerta de Hierro-Segovia de Arana , Majadahonda, Madrid, Spain., Aguilar-Pérez M; Respiratory Medicine Department, Lung Transplant Unit, Hospital Universitario Puerta de Hierro-Majadahonda, Instituto de Investigación Sanitaria Puerta de Hierro-Segovia de Arana , Majadahonda, Madrid, Spain., Gomez-Lopez A; Mycology Reference and Research Laboratory, National Center for Microbiology (CNM), ISCIII , Majadahonda, Madrid, Spain., Sancho-López A; Clinical Pharmacology Department, Hospital Universitario Puerta de Hierro-Majadahonda, Instituto de Investigación Sanitaria Puerta de Hierro-Segovia de Arana , Majadahonda, Madrid, Spain., López García-Gallo C; Respiratory Medicine Department, Lung Transplant Unit, Hospital Universitario Puerta de Hierro-Majadahonda, Instituto de Investigación Sanitaria Puerta de Hierro-Segovia de Arana , Majadahonda, Madrid, Spain., Díaz Nuevo G; Respiratory Medicine Department, Lung Transplant Unit, Hospital Universitario Puerta de Hierro-Majadahonda, Instituto de Investigación Sanitaria Puerta de Hierro-Segovia de Arana , Majadahonda, Madrid, Spain., Diago-Sempere E; Clinical Pharmacology Department, Hospital Universitario Puerta de Hierro-Majadahonda, Instituto de Investigación Sanitaria Puerta de Hierro-Segovia de Arana , Majadahonda, Madrid, Spain., Ruiz-Antorán B; Clinical Pharmacology Department, Hospital Universitario Puerta de Hierro-Majadahonda, Instituto de Investigación Sanitaria Puerta de Hierro-Segovia de Arana , Majadahonda, Madrid, Spain., Avendaño-Solá C; Clinical Pharmacology Department, Hospital Universitario Puerta de Hierro-Majadahonda, Instituto de Investigación Sanitaria Puerta de Hierro-Segovia de Arana , Majadahonda, Madrid, Spain., Ussetti-Gil P; Respiratory Medicine Department, Lung Transplant Unit, Hospital Universitario Puerta de Hierro-Majadahonda, Instituto de Investigación Sanitaria Puerta de Hierro-Segovia de Arana , Majadahonda, Madrid, Spain.
Jazyk:	angličtina
Zdroj:	Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2023 Oct 18; Vol. 67 (10), pp. e0061323. Date of Electronic Publication: 2023 Oct 03.
DOI:	10.1128/aac.00613-23
Abstrakt:	Isavuconazole's (ISA) pharmacokinetics was studied among lung transplant recipients to evaluate its bronchopulmonary penetration. This study included 13 patients and showed mean serum concentrations of 3.30 (standard deviation [SD] 0.45), 5.12 (SD 1.36), and 6.31 (SD 0.95) at 2 h, 4 h, and 24 h respectively. Mean concentrations in the epithelial lining fluid were 0.969 (SD 0.895), 2.141 (SD 1.265), and 2.812 (SD 0.693) at the same time points. ISA is a drug with a tolerable safety profile that achieves adequate concentrations in the lung. Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
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