Progress in the research of cuproptosis and possible targets for cancer therapy.

Autor:	Wang J; Children Medical Center, Hunan Provincial People's Hospital, the First Affiliated Hospital of Hunan Normal University, Changsha 410013, Hunan Province, China., Luo LZ; Children Medical Center, Hunan Provincial People's Hospital, the First Affiliated Hospital of Hunan Normal University, Changsha 410013, Hunan Province, China., Liang DM; Department of Hepatobiliary Surgery, Hunan Provincial People's Hospital, the First Affiliated Hospital of Hunan Normal University, Changsha 410013, Hunan Province, China., Guo C; Department of Hepatobiliary Surgery, Hunan Provincial People's Hospital, the First Affiliated Hospital of Hunan Normal University, Changsha 410013, Hunan Province, China., Huang ZH; Children Medical Center, Hunan Provincial People's Hospital, the First Affiliated Hospital of Hunan Normal University, Changsha 410013, Hunan Province, China., Sun GY; Department of Histology and Embryology, Hunan Normal University School of Medicine, Changsha 410013, Hunan Province, China., Wen J; Department of Pediatric Orthopedics, Hunan Provincial People's Hospital, the First Affiliated Hospital of Hunan Normal University, Changsha 410013, Hunan Province, China. cashwj@qq.com.
Jazyk:	angličtina
Zdroj:	World journal of clinical oncology [World J Clin Oncol] 2023 Sep 24; Vol. 14 (9), pp. 324-334.
DOI:	10.5306/wjco.v14.i9.324
Abstrakt:	Developing novel cancer therapies that exploit programmed cell death pathways holds promise for advancing cancer treatment. According to a recently published study in Science, copper death (cuproptosis) occurs when intracellular copper is overloaded, triggering aggregation of lipidated mitochondrial proteins and Fe-S cluster proteins. This intriguing phenomenon is triggered by the instability of copper ions. Understanding the molecular mechanisms behind cuproptosis and its associated genes, as identified by Tsvetkov, including ferredoxin 1, lipoic acid synthase, lipoyltransferase 1, dihydrolipid amide dehydrogenase, dihydrolipoamide transacetylase, pyruvate dehydrogenase α1, pyruvate dehydrogenase β, metallothionein, glutaminase, and cyclin-dependent kinase inhibitor 2A, may open new avenues for cancer therapy. Here, we provide a new understanding of the role of copper death and related genes in cancer. Competing Interests: Conflict-of-interest statement: There is no conflict of interest associated with any of the senior author or other coauthors contributed their efforts in this manuscript. (©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.)
Databáze:	MEDLINE
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