| Autor: |
Cipolla C; Department of Life Sciences and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo Francesco Vito n. 1, 00168 Rome, Italy., Lazzareschi I; Department of Life Sciences and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo Francesco Vito n. 1, 00168 Rome, Italy.; Università Cattolica Sacro Cuore, 00168 Rome, Italy., Curatola A; Department of Life Sciences and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo Francesco Vito n. 1, 00168 Rome, Italy., Lasorella C; Department of Life Sciences and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo Francesco Vito n. 1, 00168 Rome, Italy., Pane LC; Department of Life Sciences and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo Francesco Vito n. 1, 00168 Rome, Italy., Sessa L; Department of Life Sciences and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo Francesco Vito n. 1, 00168 Rome, Italy., Rotunno G; Department of Life Sciences and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo Francesco Vito n. 1, 00168 Rome, Italy., Rigante D; Department of Life Sciences and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo Francesco Vito n. 1, 00168 Rome, Italy.; Università Cattolica Sacro Cuore, 00168 Rome, Italy., Sodero G; Department of Life Sciences and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo Francesco Vito n. 1, 00168 Rome, Italy. |
| Abstrakt: |
The aim of this study was to evaluate a potential correlation between results of the oral glucose tolerance test (OGTT) and the auxological/metabolic parameters in a cohort of overweight patients assessed for suspicion of hyperinsulinism. We analyzed 206 patients, comparing those with insulin peak below (nonhyperinsulinemic) and over 100 uIU/mL (hyperinsulinemic) at the OGTT. We found a significant difference in weight ( p = 0.037), body mass index (BMI, p < 0.001) and BMI standard deviations (SD, p < 0.001), waist circumference ( p = 0.001), hip circumference ( p = 0.001), and waist-to-height ratio (WHtR, p = 0.016) between the two groups. Analyzing the median insulin value during OGTT in the whole population, a weakly positive correlation emerged with weight SD ( p < 0.001; rho = 0.292) and a moderate positive correlation with BMI SD ( p < 0.001; rho = 0.323). We also found a weakly positive correlation with waist circumference ( p = 0.001; rho = 0.214), hip circumference ( p = 0.001; rho = 0.217), and WHTR ( p = 0.016; rho = 0.209) and a moderate positive correlation with the HOMA index ( p < 0.001; rho = 0.683). The median insulin value correlates with high triglyceride ( p < 0.001; rho = 0.266) and triiodothyronine values ( p = 0.003; rho = 0.193) and with low HDL values ( p < 0.001; rho = -0.272). In clinical practice the interpretation of laboratory and anthropometric parameters could predict the level of insulin, highlighting also a possible underlying diagnosis of insulin resistance and/or hyperinsulinemia without performing an OGTT. |
