| Autor: |
Rodrigues NER; Laboratory of Farmatoxicological Prospecting of Bioactive Products (BIOFARMATOX), Department of Antibiotics, Federal University of Pernambuco (UFPE), Recife 54740-520, Pernambuco, Brazil.; Department of Medicine, University of Pernambuco (UPE), Garanhuns 53294-902, Pernambuco, Brazil., Oliveira ARDS; Laboratory of Farmatoxicological Prospecting of Bioactive Products (BIOFARMATOX), Department of Antibiotics, Federal University of Pernambuco (UFPE), Recife 54740-520, Pernambuco, Brazil., Lima SMA; Laboratory of Farmatoxicological Prospecting of Bioactive Products (BIOFARMATOX), Department of Antibiotics, Federal University of Pernambuco (UFPE), Recife 54740-520, Pernambuco, Brazil., Nunes DM; Department of Medicine, University of Pernambuco (UPE), Garanhuns 53294-902, Pernambuco, Brazil., Albuquerque PBS; Department of Medicine, University of Pernambuco (UPE), Garanhuns 53294-902, Pernambuco, Brazil., da Cunha MDGC; Biochemistry Department, Federal University of Pernambuco (UFPE), Recife 50670-420, Pernambuco, Brazil., Wanderley AG; Department of Physiology and Pharmacology, Federal University of Pernambuco (UFPE), Recife 50670-901, Pernambuco, Brazil.; Department of Pharmaceutical Sciences, Federal Univesity of São Paulo, São Paulo 09913-030, Brazil., Júnior FMRDS; Institute of Biological Sciences, Federal University of Rio Grande-FURG, Rio Grande 96293-900, Rio Grande do Sul, Brazil., Silva JBNF; Laboratory of Biotechnology, Immunology and Health Studies, Medicine Course, Federal University of Tocantins (UFT), Palmas 77001-923, Tocantins, Brazil., Teixeira ÁAC; Department of Morphology and Animal Physiology, Federal Rural University of Pernambuco (UFPE), Recife 52171-900, Pernambuco, Brazil., Silva TGD; Laboratory of Farmatoxicological Prospecting of Bioactive Products (BIOFARMATOX), Department of Antibiotics, Federal University of Pernambuco (UFPE), Recife 54740-520, Pernambuco, Brazil. |
| Abstrakt: |
Toxicological studies on medicinal plants are essential to ensure their safety and effectiveness in treating various diseases. Despite the species Chrysobalanus icaco L. being popularly used in the treatment of several diseases due to the pharmacological properties of its bioactive compounds, there are few studies in the literature regarding its toxicity regarding reproduction. Therefore, the purpose of this study was to assess the potential embryotoxic and teratogenic effects of the aqueous extract of C. icaco leaves (AECi) on Wistar rats. Animals were given AECi at doses of 100, 200, and 400 mg/kg during the pre-implantation and organogenesis periods. Data were analyzed using ANOVA followed by Tukey's test and Kruskal-Wallis. Pregnant rats treated during the pre-implantation period showed no signs of reproductive toxicity. Rats that received AECi at 100, 200, and 400 mg/kg during organogenesis did not exhibit any signs of maternal systemic toxicity or significant differences in gestational and embryotoxic parameters. Some skeletal changes were observed in the treated groups. Therefore, it can be suggested that AECi at doses of 100, 200, and 400 mg/kg is safe for treated animals and does not induce reproductive toxicity under the experimental conditions applied, but it also caused low systemic toxicity. |
