Can tumour budding change the future of pulmonary adenocarcinoma?

Autor: Ciflik KB; Department of Thoracic Surgery, Ankara City Hospital, Ankara, Turkey. Electronic address: baturhanciflik@gmail.com., Dogan HT; Department of Pathology, Ankara Yildirim Beyazit University, Ankara, Turkey. Electronic address: hayriyetatli@gmail.com., Dogan E; Department of Pathology, Ankara City Hospital, Ankara, Turkey. Electronic address: elifdogan1994@gmail.com., Ciflik BO; Department of Thoracic Surgery, Ankara Etlik City Hospital, Ankara, Turkey. Electronic address: ozdemirbusra89@gmail.com., Kocer B; Department of Thoracic Surgery, Ankara City Hospital, Ankara, Turkey. Electronic address: drbkocer@gmail.com., Karaoglanoglu N; Department of Thoracic Surgery, Ankara Yildirim Beyazit University, Ankara, Turkey. Electronic address: nkaraoglanoglu@hotmail.com., Yekeler E; Department of Thoracic Surgery, Ankara City Hospital, Ankara, Turkey. Electronic address: eyekeler@hotmail.com.
Jazyk: angličtina
Zdroj: Pathology, research and practice [Pathol Res Pract] 2023 Oct; Vol. 250, pp. 154808. Date of Electronic Publication: 2023 Sep 15.
DOI: 10.1016/j.prp.2023.154808
Abstrakt: Background: Pulmonary adenocarcinoma shows different prognosis even in the same pathological subtype and stage. In this study, it is aimed to investigate the relationship between tumour budding and known prognostic values and clinicopathological features in pulmonary adenocarcinoma.
Methods: In this study, there have been 77 patients diagnosed with primary pulmonary adenocarcinoma. In the evaluation process, the number of budding between 0 and 4 is accepted as low budding (Bd1), the number of budding between 5 and 9 is considered as medium budding (Bd2), and the number of budding above 10 is considered as high budding (Bd3).
Results: According to the findings of the study, it can be seen that there is a statistical difference between tumour budding and stromal fibrosis (p < 0.001). The presence of pleural invasion, lymph vascular invasion and perineural invasion in patients with Bd3 is found to be statistically higher than the patients with Bd1 (p = 0.048) (p = 0.041) (p = 0.029).
Conclusions: Tumour budding has been associated with pleural invasion, lymph vascular invasion, perineural invasion, and stromal fibrosis. This study is the first to show the relationship between tumour budding and stromal fibrosis in pulmonary adenocarcinomas. The role of tumour budding in lung cancers remains to be clarified.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier GmbH. All rights reserved.)
Databáze: MEDLINE
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