Comparison of innate lymphoid cells from tissue and blood in chronic tonsillitis and tonsillar hypertrophy.

Autor: Çakıcı K; Erciş Şehit Rıdvan Çevik State Hospital, Otolaryngology, Van, Turkey. Electronic address: kerim_cak@hotmail.com., Gökdoğan O; Mugla Sitki Kocman University, Faculty of Medicine, Otolaryngology, Mugla, Turkey., Genç D; Muğla Sıtkı Koçman University, Faculty of Health Sciences, Muğla, Turkey., Günaydın B; Department of Histology & Embryology, Muğla Sıtkı Koçman University, Institute of Health Sciences, Muğla, Turkey., Üçüncü H; Mugla Sitki Kocman University, Faculty of Medicine, Otolaryngology, Mugla, Turkey.
Jazyk: angličtina
Zdroj: International journal of pediatric otorhinolaryngology [Int J Pediatr Otorhinolaryngol] 2023 Nov; Vol. 174, pp. 111740. Date of Electronic Publication: 2023 Sep 19.
DOI: 10.1016/j.ijporl.2023.111740
Abstrakt: Object: Recurrent tonsillitis and tonsillar hypertrophy are two common diseases in children for which tonsillectomy is the definitive solution. The underlying causes of both diseases are not fully known. The aim of this study was to identify the predominant innate lymphoid cells in both diseases of the palatine tonsils, which are known to play an important role in the immune system.
Methods: Children who underwent tonsillectomy were divided into two groups as recurrent tonsillitis and tonsillar hypertrophy according to the indication for surgery. The proportions of innate lymphoid cell (ILC) groups and IFN-gamma, IL-10 and IL-17 secreting T lymphocyte cells were determined in tonsil and blood samples obtained during surgery. Local and peripheral immune responses were evaluated. Innate immune responses and acquired immune responses were compared.
Results: The results of our study showed that the proportions of the innate lymphoid cell 1 group (ILC1) were similar in tonsil tissue in patients with recurrent tonsillitis and tonsil hypertrophy, with no statistically significant difference. It was observed that the innate lymphoid cell 2 group (ILC2) was the predominant group in tonsil hypertrophy, the innate lymphoid cell 3 group (ILC3) was the predominant innate lymphoid cell group in recurrent tonsillitis, and the proportion of IL-17 secreting T lymphocytes in blood and tonsillar mononuclear cells was higher in recurrent tonsillitis patients than in tonsil hypertrophy patients.
Conclusion: With the results obtained, the predominant innate lymphoid cells in the pathogenesis of both diseases were identified and local and peripheral responses were compared. These findings may be a guide for possible medical treatments for both diseases in the future.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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