Influence of umbilical cord vitamin D serum levels on the growth of preterm infants.

Autor: Mori JD; Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil., Kassai MS; Pediatric Department of Centro Universitário FMABC, São Paulo, Brazil., Lebrão CW; Neonatal Unit, Hospital da Mulher - São Bernardo do Campo, São Paulo, Brazil., Affonso-Fonseca FL; Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil; Clinical Analysis, Department of Pathology of Centro Universitário Faculdade FMABC, São Paulo, Brazil., Sarni ROS; Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil; Department of Pediatrics, Centro Universitário FMABC, São Paulo, Brazil., Suano-Souza FI; Pediatric Department of Centro Universitário FMABC, São Paulo, Brazil; Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil. Electronic address: suano.souza@unifesp.br.
Jazyk: angličtina
Zdroj: Nutrition (Burbank, Los Angeles County, Calif.) [Nutrition] 2023 Dec; Vol. 116, pp. 112194. Date of Electronic Publication: 2023 Aug 14.
DOI: 10.1016/j.nut.2023.112194
Abstrakt: Objective: The aim of this study was to evaluate the influence of serum 25-hydroxyvitamin D [25(OH)D] levels at birth in postnatal growth at discharge and 12 mo of corrected age in preterm infants.
Methods: This prospective cohort included 63 preterm newborns born before 34 gestational weeks evaluated from birth until 12 mo of corrected age. The serum 25(OH)D levels in umbilical cord blood and from their mothers were evaluated at delivery.
Results: The mean 25(OH)D levels in preterm newborns were higher than maternal levels (24.8 ± 13.3 ng/mL versus 21 ± 10.2 ng/mL, P < 0.001) and showed a moderate correlation between (r = 0.548; P < 0.001). Considering the body mass index Z-score at 12 mo, 3 (10%), 25 (83%), and 2 (7%) of the preterm infants were thin, had normal body mass index, and were overweight, respectively. The 25(OH)D levels in the umbilical cord did not influence the anthropometric indicators at hospital discharge and 12 mo of corrected age. We observed improvement in all anthropometric indicators assessed over the months, and there was no difference between preterm infants with 25(OH)D levels >20 ng/mL and <20 ng/mL in the umbilical cord.
Conclusions: The results of this study suggested that the 25(OH)D serum levels in the umbilical cord did not influence postnatal growth from birth to the first year of life in preterm infants. There was a direct association between maternal and umbilical cord serum 25(OH)D levels.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: