Liver ischemia-reperfusion injury: From trigger loading to shot firing.

Autor:	Felli E; Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland.; Department for BioMedical Research, Visceral Surgery and Medicine, University of Bern, Switzerland., Felli E; Department of Digestive Surgery and Liver Transplantation, University Hospital of Tours, France., Muttillo EM; Department of Medical Surgical Science and Translational Medicine, Sant' Andrea Hospital, Sapienza University of Rome, Rome, Italy., Urade T; Department of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Kobe University Graduate School of Medicine, Japan., Laracca GG; Department of Medical Surgical Science and Translational Medicine, Sant' Andrea Hospital, Sapienza University of Rome, Rome, Italy., Giannelli V; Department of Transplantation and General Surgery, San Camillo Hospital, Italy., Famularo S; Department of Biomedical Science, Humanitas University Pieve Emanuele, Italy.; Department of Hepatobiliary and General Surgery, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.; Research Institute Against Cancer of the Digestive System (IRCAD), France., Geny B; Institute of Physiology, EA3072 Mitochondria Respiration and Oxidative Stress, University of Strasbourg, France., Ettorre GM; Department of Transplantation and General Surgery, San Camillo Hospital, Italy., Rombouts K; University College London - Institute for Liver and Digestive Health, Royal Free Hospital, NW3 2PF London, United Kingdom., Pinzani M; University College London - Institute for Liver and Digestive Health, Royal Free Hospital, NW3 2PF London, United Kingdom., Diana M; Research Institute Against Cancer of the Digestive System (IRCAD), France., Gracia-Sancho J; Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland.; Department for BioMedical Research, Visceral Surgery and Medicine, University of Bern, Switzerland.; Liver Vascular Biology Research Group, IDIBAPS Biomedical Research Institute, Hospital Clínic Barcelona, CIBEREHD, Barcelona, Spain.
Jazyk:	angličtina
Zdroj:	Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society [Liver Transpl] 2023 Nov 01; Vol. 29 (11), pp. 1226-1233. Date of Electronic Publication: 2023 Sep 21.
DOI:	10.1097/LVT.0000000000000252
Abstrakt:	An ischemia-reperfusion injury (IRI) results from a prolonged ischemic insult followed by the restoration of blood perfusion, being a common cause of morbidity and mortality, especially in liver transplantation. At the maximum of the potential damage, IRI is characterized by 2 main phases. The first is the ischemic phase, where the hypoxia and vascular stasis induces cell damage and the accumulation of damage-associated molecular patterns and cytokines. The second is the reperfusion phase, where the local sterile inflammatory response driven by innate immunity leads to a massive cell death and impaired liver functionality. The ischemic time becomes crucial in patients with underlying pathophysiological conditions. It is possible to compare this process to a shooting gun, where the loading trigger is the ischemia period and the firing shot is the reperfusion phase. In this optic, this article aims at reviewing the main ischemic events following the phases of the surgical timeline, considering the consequent reperfusion damage. (Copyright © 2023 American Association for the Study of Liver Diseases.)
Databáze:	MEDLINE
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