Harnessing role of sesamol and its nanoformulations against neurodegenerative diseases.

Autor: Singh N; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India., Vishwas S; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India., Kaur A; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India., Kaur H; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India., Kakoty V; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India., Khursheed R; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India., Chaitanya MVNL; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India., Babu MR; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India., Awasthi A; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India; Department of pharmaceutics, ISF college of Pharmacy, Moga, Punjab 142001, India., Corrie L; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India., Harish V; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India., Yanadaiah P; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India., Gupta S; Chameli Devi Institute of Pharmacy, Department of pharmacology, Khandwa Road, Village Umrikheda, Near Toll booth, Indore, Madhya Pradesh 452020, India., Sayed AA; Zoology Department, Faculty of Science, Cairo University, Giza 12613, Egypt., El-Sayed A; Department of Animal Infectious Diseases, Faculty of Veterinary medicine, Cairo University, Egypt., Ali I; Department of Biochemistry and Cell Biology, State University of New York at Stonybrook, New York, USA., Kensara OA; Department of Clinical Nutrition, Faculty of Applied Medical Sciences, Umm Al-Qura University, P.O. Box 7067, Makkah 21955, Saudi Arabia., Ghaboura N; Department of Pharmacy Practice, Pharmacy Program, Batterjee Medical College, P. O. Box 6231, Jeddah 21442, Saudi Arabia., Gupta G; Center for Global Health Research, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, India; School of Pharmacy, Graphic Era Hill University, Dehradun 248007, India; School of Pharmacy, Suresh Gyan Vihar University, Mahal Road, Jagatpura 302017, Jaipur, India., Dou AM; Division of blood bank, Department of medical laboratories, Riyadh security forces hospital, Ministry of interior, Riyadh, Saudi Arabia., Algahtani M; Department of Laboratory & Blood Bank, Security Forces Hospital, Mecca, Saudi Arabia., El-Kott AF; Department of Biology, College of Science, King Khalid University, Abha, Saudi Arabia; Department of Zoology, College of Science, Damanhour University, Egypt., Dua K; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW 2007, Australia; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, Australia; Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India., Singh SK; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, Australia. Electronic address: singhsachin23@gmail.com., Abdel-Daim MM; Department of Pharmaceutical Sciences, Pharmacy Program, Batterjee Medical College, P.O. Box 6231, Jeddah 21442, Saudi Arabia; Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt. Electronic address: abdeldaim.m@vet.suez.edu.eg.
Jazyk: angličtina
Zdroj: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2023 Nov; Vol. 167, pp. 115512. Date of Electronic Publication: 2023 Sep 17.
DOI: 10.1016/j.biopha.2023.115512
Abstrakt: Sesamol is a lignan of sesame seeds and a natural phenolic molecule that has emerged as a useful medical agent. Sesamol is a non-toxic phytoconstituent, which exerts certain valuable effects in the management of cancer, diabetes, cardiovascular diseases, neurodegenerative diseases (NDs), etc. Sesamol is known to depict its neuroprotective role by various mechanisms, such as metabolic regulators, action on oxidative stress, neuroinflammation, etc. However, its poor oral bioavailability, rapid excretion (as conjugates), and susceptibility to gastric irritation/toxicity (particularly in rats' forestomach) may restrict its effectiveness. To overcome the associated limitations, novel drug delivery system-based formulations of sesamol are emerging and being researched extensively. These can conjugate with sesamol and enhance the bioavailability and solubility of free sesamol, along with delivery at the target site. In this review, we have summarized various research works highlighting the role of sesamol on various NDs, including Alzheimer's disease, Huntington's disease, Amyotrophic lateral sclerosis, and Parkinson's disease. Moreover, the formulation strategies and neuroprotective role of sesamol-based nano-formulations have also been discussed.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
Databáze: MEDLINE
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