Intravenous or subcutaneous natalizumab in patients with relapsing-remitting multiple sclerosis: investigation on efficiency and savings-the EASIER study.

Autor: Filippi M; Neurology Unit, Neurorehabilitation Unit, Neurophysiology Service, and Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Via Olgettina, 60, 20132, Milan, Italy. filippi.massimo@hsr.it.; Vita-Salute San Raffaele University, Milan, Italy. filippi.massimo@hsr.it., Grimaldi L; Multiple Sclerosis Center, Institute Foundation G. Giglio, Cefalù, PA, Italy., Conte A; Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy.; Multiple Sclerosis Center, Policlinico Umberto I Hospital, Rome, Italy.; IRCCS Neuromed, Pozzilli, IS, Italy., Totaro R; Demyelinating Disease Center, Department of Neurology, San Salvatore Hospital, L'Aquila, Italy., Valente MR; Clinical Neurology, Santa Maria della Misericordia University Hospital, and Department of Medicine, University of Udine, Udine, Italy., Malucchi S; SCDO Neurologia, S. Luigi Gonzaga University Hospital, Orbassano, TO, Italy., Granella F; Department of Medicine and Surgery, University Hospital of Parma, Parma, Italy., Cordioli C; Multiple Sclerosis Center, ASST Spedali Civili di Brescia, Montichiari Hospital (Brescia), Brescia, Italy., Brescia Morra V; Multiple Sclerosis Clinical Care and Research Center, Department of Neuroscience (NSRO), Federico II University Hospital, Naples, Italy., Zanetta C; Neurology Unit, Neurorehabilitation Unit, Neurophysiology Service, and Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Via Olgettina, 60, 20132, Milan, Italy., Perini D; Biogen Italia, Milan, Italy., Santoni L; Biogen Italia, Milan, Italy.
Jazyk: angličtina
Zdroj: Journal of neurology [J Neurol] 2024 Jan; Vol. 271 (1), pp. 340-354. Date of Electronic Publication: 2023 Sep 16.
DOI: 10.1007/s00415-023-11955-0
Abstrakt: Introduction: EASIER is a multicenter, observational, cross-sectional study investigating the consumption of healthcare resources, including healthcare professional (HCP) active working time, the costs associated with the current natalizumab intravenous (IV) administration, and the potential impact of the adoption of subcutaneous (SC) route.
Methods: The EASIER study has three parts: (1) time and motion study to measure healthcare resources and working time needed for natalizumab IV administration using a digital data collection tool operated directly by HCPs; (2) HCP structured questionnaire-based estimation of the potential impact of natalizumab SC vs. IV administration; and (3) patient survey on the burden of natalizumab administration.
Results: Nine Italian multiple sclerosis (MS) centers measured 404 IV natalizumab administration procedures and administered 26 HCP questionnaires and 297 patient questionnaires. Patients had a mean of 52 (range 1-176) previous IV administrations and spent a mean (median, IQR) of 152 (130, 94-184) minutes in the center per each IV procedure, with IV infusion covering 50% of the total. Including patient travel time, an average of 5 h was dedicated to each IV administration. Active working time by HCP amounted to 29 min per IV administration procedure, 70% of which by nursing staff. With adoption of the SC route, HCPs estimated a 50% reduction in patient procedure time and 55% lower HCP active working time. This translated into a 63% cost reduction for the MS center per natalizumab administration procedure.
Conclusions: SC natalizumab administration will consistently reduce consumption of patient and HCP times per procedure and associated costs.
(© 2023. The Author(s).)
Databáze: MEDLINE
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