Discovery medicine - the HVTN's iterative approach to developing an HIV-1 broadly neutralizing vaccine.
| Autor: | Martin TM; Fred Hutchinson Cancer Center, Seattle, Washington, USA., Robinson ST, Huang Y |
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| Jazyk: | angličtina |
| Zdroj: | Current opinion in HIV and AIDS [Curr Opin HIV AIDS] 2023 Nov 01; Vol. 18 (6), pp. 290-299. Date of Electronic Publication: 2023 Sep 13. |
| DOI: | 10.1097/COH.0000000000000821 |
| Abstrakt: | Purpose of Review: In the past two decades, there has been an explosion in the discovery of HIV-1 broadly neutralizing antibodies (bnAbs) and associated vaccine strategies to induce them. This abundance of approaches necessitates a system that accurately and expeditiously identifies the most promising regimens. We herein briefly review the background science of bnAbs, provide a description of the first round of phase 1 discovery medicine studies, and suggest an approach to integrate these into a comprehensive HIV-1-neutralizing vaccine. Recent Findings: With recent preclinical success including induction of early stage bnAbs in mouse knockin models and rhesus macaques, successful priming of VRC01-class bnAbs with eOD-GT8 in a recent study in humans, and proof-of-concept that intravenous infusion of VRC01 prevents sexual transmission of virus in humans, the stage is set for a broad and comprehensive bnAb vaccine program. Leveraging significant advances in protein nanoparticle science, mRNA technology, adjuvant development, and B-cell and antibody analyses, the HVTN has reconfigured its HIV-1 vaccine strategy by developing the Discovery Medicine Program to test promising vaccine candidates targeting six key epitopes. Summary: The HVTN Discovery Medicine program is testing multiple HIV-1-neutralizing vaccine candidates. (Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.) |
| Databáze: | MEDLINE |
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