Targeted curation of the gut microbial gene content modulating human cardiovascular disease.

Autor:	Borton MA; Department of Soil and Crop Sciences, Colorado State University , Fort Collins, Colorado, USA., Shaffer M; Department of Soil and Crop Sciences, Colorado State University , Fort Collins, Colorado, USA., Hoyt DW; Environmental and Biological Sciences Directorate, Pacific Northwest National Laboratory , Richland, Washington, USA., Jiang R; Department of Microbiology, The Ohio State University , Columbus, Ohio, USA., Ellenbogen JB; Department of Microbiology, The Ohio State University , Columbus, Ohio, USA., Purvine S; Environmental and Biological Sciences Directorate, Pacific Northwest National Laboratory , Richland, Washington, USA., Nicora CD; Environmental and Biological Sciences Directorate, Pacific Northwest National Laboratory , Richland, Washington, USA., Eder EK; Environmental and Biological Sciences Directorate, Pacific Northwest National Laboratory , Richland, Washington, USA., Wong AR; Environmental and Biological Sciences Directorate, Pacific Northwest National Laboratory , Richland, Washington, USA., Smulian AG; Department of Internal Medicine, University of Cincinnati , Cincinnati, Ohio, USA., Lipton MS; Environmental and Biological Sciences Directorate, Pacific Northwest National Laboratory , Richland, Washington, USA., Krzycki JA; Department of Microbiology, The Ohio State University , Columbus, Ohio, USA., Wrighton KC; Department of Soil and Crop Sciences, Colorado State University , Fort Collins, Colorado, USA.
Jazyk:	angličtina
Zdroj:	MBio [mBio] 2023 Oct 31; Vol. 14 (5), pp. e0151123. Date of Electronic Publication: 2023 Sep 11.
DOI:	10.1128/mbio.01511-23
Abstrakt:	Importance: One of the most-cited examples of the gut microbiome modulating human disease is the microbial metabolism of quaternary amines from protein-rich foods. By-products of this microbial processing promote atherosclerotic heart disease, a leading cause of human mortality globally. Our research addresses current knowledge gaps in our understanding of this microbial metabolism by holistically inventorying the microorganisms and expressed genes catalyzing critical atherosclerosis-promoting and -ameliorating reactions in the human gut. This led to the creation of an open-access resource, the Methylated Amine Gene Inventory of Catabolism database, the first systematic inventory of gut methylated amine metabolism. More importantly, using this resource we deliver here, we show for the first time that these gut microbial genes can predict human disease, paving the way for microbiota-inspired diagnostics and interventions. Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
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