| Autor: |
Sabóia Guerra Diógenes É; Department of Pharmacy, Federal University of Ceará, Fortaleza, Ceará, Brazil., da Silva ALC; Department of Pharmacy, Federal University of Ceará, Fortaleza, Ceará, Brazil., Chagas Neto FCD; Department of Pharmacy, Federal University of Ceará, Fortaleza, Ceará, Brazil., Silveira ER; Department of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, Ceará, Brazil., Leal LKAM; Department of Pharmacy, Federal University of Ceará, Fortaleza, Ceará, Brazil., Nicolete R; Oswaldo Cruz Foundation (Fiocruz Ceará), Eusébio, Ceará, Brazil., de Araújo TG; Department of Pharmacy, Federal University of Ceará, Fortaleza, Ceará, Brazil. |
| Abstrakt: |
Myracrodruon urundeuva , popularly known as 'aroeira-do-sertão', a large tree, with a tall trunk. Belonging to the Anacardiaceae family, it occurs in the 'caatinga' and dry forests of Brazil, from Ceará to the states of Paraná and Mato Grosso do Sul. The present study aimed to analyse the whitening and antioxidant activities of the aqueous extract of the leaves of Myracrodruon urundeuva (AELMU). Inhibition of the tyrosinase enzyme, as well as its copper chelating capacity and antioxidant effect were evaluated. The AELMU (at 2000 µg/mL) showed excellent inhibitory action (83.76%) on tyrosinase by chelating the copper ion while kojic acid at the same concentration inhibited 97.81%. Moreover, the extract displayed important antioxidant activity (inhibited 76,46% of the 2,2-diphenyl-1-picrylhydrazyl radical - DPPH; 49,59% of thiobarbituric acid reactive substances and 51,07% of the hydroxyl radical). Thus, the extract under study is promising for use in cosmetics, given its multifactorial action. |
