Space wandering in the rodent default mode network.

Autor:	Nghiem TE; Department of Psychiatry & Behavioral Sciences, Stanford University., Lee B; Department of Psychiatry & Behavioral Sciences, Stanford University., Chao TH; Center for Animal MRI, University of North Carolina at Chapel Hill.; Biomedical Research Imaging Center, University of North Carolina at Chapel Hill.; Department of Neurology, University of North Carolina at Chapel Hill., Branigan NK; Department of Psychiatry & Behavioral Sciences, Stanford University., Mistry PK; Department of Psychiatry & Behavioral Sciences, Stanford University., Shih YI; Center for Animal MRI, University of North Carolina at Chapel Hill.; Biomedical Research Imaging Center, University of North Carolina at Chapel Hill.; Department of Neurology, University of North Carolina at Chapel Hill.; Department of Biomedical Engineering, University of North Carolina at Chapel Hill., Menon V; Department of Psychiatry & Behavioral Sciences, Stanford University.; Department of Neurology & Neurological Sciences, Stanford University.; Wu Tsai Neurosciences Institute, Stanford University.
Jazyk:	angličtina
Zdroj:	BioRxiv : the preprint server for biology [bioRxiv] 2023 Sep 01. Date of Electronic Publication: 2023 Sep 01.
DOI:	10.1101/2023.08.31.555793
Abstrakt:	The default mode network (DMN) is a large-scale brain network known to be suppressed during a wide range of cognitive tasks. However, our comprehension of its role in naturalistic and unconstrained behaviors has remained elusive because most research on the DMN has been conducted within the restrictive confines of MRI scanners. Here we use multisite GCaMP fiber photometry with simultaneous videography to probe DMN function in awake, freely exploring rats. We examined neural dynamics in three core DMN nodes- the retrosplenial cortex, cingulate cortex, and prelimbic cortex- as well as the anterior insula node of the salience network, and their association with the rats' spatial exploration behaviors. We found that DMN nodes displayed a hierarchical functional organization during spatial exploration, characterized by stronger coupling with each other than with the anterior insula. Crucially, these DMN nodes encoded the kinematics of spatial exploration, including linear and angular velocity. Additionally, we identified latent brain states that encoded distinct patterns of time-varying exploration behaviors and discovered that higher linear velocity was associated with enhanced DMN activity, heightened synchronization among DMN nodes, and increased anticorrelation between the DMN and anterior insula. Our findings highlight the involvement of the DMN in collectively and dynamically encoding spatial exploration in a real-world setting. Our findings challenge the notion that the DMN is primarily a "task-negative" network disengaged from the external world. By illuminating the DMN's role in naturalistic behaviors, our study underscores the importance of investigating brain network function in ecologically valid contexts. Competing Interests: Competing interests: The authors declare no competing interest.
Databáze:	MEDLINE
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