Chia (Salvia hispanica L.) flour modulates the intestinal microbiota in Wistar rats fed a high-fat and high-fructose diet.

Autor: Morais VN; Department of Nutrition and Health, Federal University of Viçosa, Viçosa 36570-900, MG, Brazil., Gomes MJC; Department of Nutrition and Health, Federal University of Viçosa, Viçosa 36570-900, MG, Brazil., Grancieri M; Department of Pharmacy and Nutrition, Federal University of Espírito Santo, Alegre 29500-000, ES, Brazil., Moreira LPD; Department of Agronomy Food Natural Resources Animals and Environment, University of Padova, Legnaro 16,35020, PD, Italy; Faculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås 1430, Viken, Norway., Toledo RCL; Department of Nutrition and Health, Federal University of Viçosa, Viçosa 36570-900, MG, Brazil., Costa NMB; Department of Pharmacy and Nutrition, Federal University of Espírito Santo, Alegre 29500-000, ES, Brazil., da Silva BP; Department of Nutrition and Health, Federal University of Viçosa, Viçosa 36570-900, MG, Brazil., Martino HSD; Department of Nutrition and Health, Federal University of Viçosa, Viçosa 36570-900, MG, Brazil. Electronic address: hercia@ufv.br.
Jazyk: angličtina
Zdroj: Food research international (Ottawa, Ont.) [Food Res Int] 2023 Oct; Vol. 172, pp. 113095. Date of Electronic Publication: 2023 Jun 10.
DOI: 10.1016/j.foodres.2023.113095
Abstrakt: A diet rich in sugar and fat can promote metabolic disorders development, especially in the intestine. Chia flour (Salvia hispanica. L) is a source of dietary fiber, alpha-linolenic fatty acid (ALA), bioactive peptides, and phenolics, promoting health benefits. This study aimed to analyze chia flour's effect on gut microbiota modulation and intestinal health in adult male Wistar rats fed a high-fat and high-fructose (HFHF) diet. Male Wistar rats (n = 10/group) were fed the diets standard (AIN-93M) or HFHF (31% saturated fat and 20% fructose) in the first phase to induce metabolic disorders. In the second phase, the rats were fed AIN-93M, HFHF, or HFHF plus 14.7% chia flour (HFHF + CF) for 10 weeks. The consumption of chia flour increased the ALA (3.24 ± 0.24) intake and significantly improved immunoglobulin A (IgA) levels (1126.00 ± 145.90), goblet cells number (24.57 ± 2.76), crypt thickness (34.37 ± 5.86), crypt depth (215.30 ± 23.19), the longitudinal muscle layer (48.11 ± 5.04), cecum weight (4.39 ± 0.71), Shannon index (p < 0.05), and significantly increased the production of acetic (20.56 ± 4.10) and butyric acids (5.96 ± 1.50), Monoglobus sp., Lachnospiraceae sp., and Prevotellaceae sp. abundance. Furthermore, chia significantly reduced the cecal pH content (7.54 ± 1.17), body mass index (0.62 ± 0.03) and weight (411.00 ± 28.58), and Simpson index (p < 0.05). Therefore, chia intake improved intestinal health parameters and functionality in rats with metabolic disorders, which demonstrates to be an effective strategy for gut microbiota modulation.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023. Published by Elsevier Ltd.)
Databáze: MEDLINE
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