| Autor: |
Palomar A; Reproductive Biology and Bioengineering in Human Reproduction, IVIRMA Global Research Alliance IVI Foundation-Health Research Institute La Fe (IIS La Fe), 46026 Valencia, Spain., Gonzalez-Martin R; Reproductive Biology and Bioengineering in Human Reproduction, IVIRMA Global Research Alliance IVI Foundation-Health Research Institute La Fe (IIS La Fe), 46026 Valencia, Spain., Quiñonero A; Reproductive Biology and Bioengineering in Human Reproduction, IVIRMA Global Research Alliance IVI Foundation-Health Research Institute La Fe (IIS La Fe), 46026 Valencia, Spain., Pellicer N; Reproductive Biology and Bioengineering in Human Reproduction, IVIRMA Global Research Alliance IVI Foundation-Health Research Institute La Fe (IIS La Fe), 46026 Valencia, Spain., Fernandez-Saavedra R; Chemistry Division, Department of Technology, Research Centre for Energy, Environment and Technology (CIEMAT), 28040 Madrid, Spain., Rucandio I; Chemistry Division, Department of Technology, Research Centre for Energy, Environment and Technology (CIEMAT), 28040 Madrid, Spain., Fernandez-Martinez R; Chemistry Division, Department of Technology, Research Centre for Energy, Environment and Technology (CIEMAT), 28040 Madrid, Spain., Conde-Vilda E; Chemistry Division, Department of Technology, Research Centre for Energy, Environment and Technology (CIEMAT), 28040 Madrid, Spain., Quejido AJ; Chemistry Division, Department of Technology, Research Centre for Energy, Environment and Technology (CIEMAT), 28040 Madrid, Spain., Zuckerman C; Department of Clinical Research, IVIRMA Global Research Alliance IVI-RMA New Jersey, Basking Ridge, NJ 07920, USA., Whitehead C; Department of Clinical Research, IVIRMA Global Research Alliance IVI-RMA New Jersey, Basking Ridge, NJ 07920, USA., Scott RT; Department of Clinical Research, IVIRMA Global Research Alliance IVI-RMA New Jersey, Basking Ridge, NJ 07920, USA.; Sidney Kimmel College of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA., Dominguez F; Reproductive Biology and Bioengineering in Human Reproduction, IVIRMA Global Research Alliance IVI Foundation-Health Research Institute La Fe (IIS La Fe), 46026 Valencia, Spain. |
| Abstrakt: |
This study aims to determine the association of non-essential trace elements present in follicular fluid, plasma, and urine with reproductive outcomes of women undergoing intracytoplasmic sperm injection (ICSI), preimplantation genetic testing for aneuploidies (PGT-A) and single frozen euploid embryo transfer (SET/FET). This single-center, prospective cohort study included sixty women undergoing ICSI with PGT-A and SET/FET between 2018 and 2019. Urine, plasma and follicular fluid samples were collected on the vaginal oocyte retrieval day to simultaneously quantify ten non-essential trace elements (i.e., Ba, Sr, Rb, Sn, Ti, Pb, Cd, Hg, Sb, and As). We found several associations between the levels of these non-essential trace elements and clinical IVF parameters. Specifically, the increased levels of barium in follicular fluid were negatively associated with ovarian function, pre-implantation development and embryo euploidy, while elevated strontium concentrations in this biofluid were negatively associated with impaired blastulation and embryo euploidy. Elevated plasma strontium levels were negatively associated with ovarian function, fertilization and blastulation. Enhanced presence of other trace elements in plasma (i.e., rubidium and arsenic) were associated with a diminished ovarian function and limited the number of recovered oocytes, mature oocytes and zygotes, respectively. Fully adjusted models suggested significantly lower odds of achieving a live birth when increased concentrations of barium and tin were found in urine. |
