Cerebellar Nuclei Receiving Orofacial Proprioceptive Signals through the Mossy Fiber Pathway from the Supratrigeminal Nucleus in Rats.

Autor: Tsutsumi Y; Department of Systematic Anatomy and Neurobiology, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka, 565-0871, Japan., Morita Y; Department of Dental Anesthesiology, Osaka University Graduate School of Dentistry, Suita, Osaka, 565-0871, Japan., Sato F; Department of Systematic Anatomy and Neurobiology, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka, 565-0871, Japan., Furuta T; Department of Systematic Anatomy and Neurobiology, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka, 565-0871, Japan., Uchino K; Department of Acupuncture, Faculty of Health Care Sciences, Takarazuka University of Medical and Health Care, Takarazuka, Hyogo, 666-0162, Japan., Sohn J; Department of Systematic Anatomy and Neurobiology, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka, 565-0871, Japan., Haque T; Department of Preventive Sciences, College of Dentistry, Dar Al Uloom University, Riyadh, 13314, Saudi Arabia., Bae YC; Department of Anatomy and Neurobiology, School of Dentistry, Kyungpook National University, Daegu, 700-412, Korea., Niwa H; Department of Dental Anesthesiology, Osaka University Graduate School of Dentistry, Suita, Osaka, 565-0871, Japan., Tachibana Y; Division of Physiology and Cell Biology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki, Chuo, Kobe, Hyogo, 650-0017, Japan. yoshi@med.kobe-u.ac.jp., Yoshida A; Department of Systematic Anatomy and Neurobiology, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka, 565-0871, Japan. yoshida.atsushi.dent@osaka-u.ac.jp.; Department of Oral Health Sciences, Faculty of Health Care Sciences, Takarazuka University of Medical and Health Care, Takarazuka, Hyogo, 666-0162, Japan. yoshida.atsushi.dent@osaka-u.ac.jp.
Jazyk: angličtina
Zdroj: Cerebellum (London, England) [Cerebellum] 2024 Oct; Vol. 23 (5), pp. 1795-1810. Date of Electronic Publication: 2023 Sep 08.
DOI: 10.1007/s12311-023-01602-9
Abstrakt: Proprioception from muscle spindles is necessary for motor function executed by the cerebellum. In particular, cerebellar nuclear neurons that receive proprioceptive signals and send projections to the lower brainstem or spinal cord play key roles in motor control. However, little is known about which cerebellar nuclear regions receive orofacial proprioception. Here, we investigated projections to the cerebellar nuclei from the supratrigeminal nucleus (Su5), which conveys the orofacial proprioception arising from jaw-closing muscle spindles (JCMSs). Injections of an anterograde tracer into the Su5 resulted in a large number of labeled axon terminals bilaterally in the dorsolateral hump (IntDL) of the cerebellar interposed nucleus (Int) and the dorsolateral protuberance (MedDL) of the cerebellar medial nucleus. In addition, a moderate number of axon terminals were ipsilaterally labeled in the vestibular group Y nucleus (group Y). We electrophysiologically detected JCMS proprioceptive signals in the IntDL and MedDL. Retrograde tracing analysis confirmed bilateral projections from the Su5 to the IntDL and MedDL. Furthermore, anterograde tracer injections into the external cuneate nucleus (ECu), which receives other proprioceptive input from forelimb/neck muscles, resulted in only a limited number of ipsilaterally labeled terminals, mainly in the dorsomedial crest of the Int and the group Y. Taken together, the Su5 and ECu axons almost separately terminated in the cerebellar nuclei (except for partial overlap in the group Y). These data suggest that orofacial proprioception is differently processed in the cerebellar circuits in comparison to other body-part proprioception, thus contributing to the executive function of orofacial motor control.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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