[Serum brain damage biomarkers as a diagnostic and prognostic tool in ischemic stroke].

Autor:	Chaykovskaya AD; Almazov National Medical Research Center, St. Petersburg, Russia., Topuzova MP; Almazov National Medical Research Center, St. Petersburg, Russia., Ternovykh IK; Almazov National Medical Research Center, St. Petersburg, Russia., Makhanova AM; Almazov National Medical Research Center, St. Petersburg, Russia., Mikheeva AG; Almazov National Medical Research Center, St. Petersburg, Russia., Pospelova ML; Almazov National Medical Research Center, St. Petersburg, Russia., Panina EB; Almazov National Medical Research Center, St. Petersburg, Russia., Vavilova TV; Almazov National Medical Research Center, St. Petersburg, Russia., Vasilieva EY; Almazov National Medical Research Center, St. Petersburg, Russia., Shustova TA; Almazov National Medical Research Center, St. Petersburg, Russia., Alekseeva TM; Almazov National Medical Research Center, St. Petersburg, Russia.
Jazyk:	ruština
Zdroj:	Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova [Zh Nevrol Psikhiatr Im S S Korsakova] 2023; Vol. 123 (8. Vyp. 2), pp. 37-46.
DOI:	10.17116/jnevro202312308237
Abstrakt:	Objective: To study serum quantities of neuron specific enolase (NSE), glial fibrillary acidic protein (GFAP) and NR2-antibodies (NR2-ab) in various cerebrovascular pathology and assess their value as a panel used as a diagnostic and predictive tool for stroke. Material and Methods: NSE, GFAP and NR2-ab serum levels were measured twice for 84 patients with ischemic stroke (IS) and 8 patients with hemorrhagic stroke (HI), once for 8 patients with transient ischemic attack (TIA), 26 patients with chronic brain ischemia (CBI), 27 healthy volunteers (HV). Results: NSE and GFAP levels were significantly higher in IS than in CBI and HV patients, and NR2-ab levels in IS were higher than in TIA and lower than in HV. In patients with more pronounced neurological deficiency and less favorable functional outcome by day 10-14 of IS, the levels of NSE, GFAP and NR2-ab were higher. Sensitivity and specificity of biomarker panel was higher than with their separate application. Conclusion: The NSE, GFAP and NR2-ab biomarkers have a diagnostic and predictive value for IS.
Databáze:	MEDLINE
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