Undiagnosed Factor VII Deficiency in Cardiac Surgery Complicated by Bleeding: A Case Report.

Autor:	Knio ZO; From the Department of Anesthesiology., Ising MS; Division of Thoracic and Cardiovascular Surgery, University of Virginia, Charlottesville, Virginia., Yount KW; Division of Thoracic and Cardiovascular Surgery, University of Virginia, Charlottesville, Virginia., Tanaka K; Department of Anesthesiology, University of Oklahoma, Oklahoma City, Oklahoma., McNeil JS; From the Department of Anesthesiology.
Jazyk:	angličtina
Zdroj:	A&A practice [A A Pract] 2023 Sep 06; Vol. 17 (9), pp. e01713. Date of Electronic Publication: 2023 Sep 06 (Print Publication: 2023).
DOI:	10.1213/XAA.0000000000001713
Abstrakt:	Rare bleeding disorders in the perioperative period call for targeted resuscitation strategies. Factor VII deficiency, for instance, is often corrected with exogenous administration of recombinant factor VIIa. This activated clotting factor, initially designed for patients with hemophilia A or B with factor inhibitors, is gaining popularity as a salvage therapy for severe and persistent traumatic and surgical bleeding. This article describes the management of a cardiothoracic surgical patient with undiagnosed isolated factor VII deficiency who experienced significant postoperative bleeding which subsided after the administration of recombinant factor VIIa. In this case, EXTEM failed to detect a clotting factor deficiency. Competing Interests: The authors declare no conflicts of interest. (Copyright © 2023 International Anesthesia Research Society.)
Databáze:	MEDLINE
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