Urinary tract infection in diabetics hospitalized in Befelatanana Hospital, Antananarivo: Epidemiological, clinical, biological profiles and risk factors for multidrug-resistant bacterial infection.

Autor: Raherison RE; Endocrinology Department Joseph Raseta Befelatanana University Hospital Center Antananarivo Madagascar., Raharinavalona SA; Internal Medicine and Cardiovascular Diseases Departments Soavinandriana Hospital Center Antananarivo Madagascar., Razanamparany T; Endocrinology Department Joseph Raseta Befelatanana University Hospital Center Antananarivo Madagascar., Randrianotahiana TN; Endocrinology Department Joseph Raseta Befelatanana University Hospital Center Antananarivo Madagascar., Randrianomanana TV; Endocrinology Department Joseph Raseta Befelatanana University Hospital Center Antananarivo Madagascar., Andrianiaina MMA; Endocrinology Department Joseph Raseta Befelatanana University Hospital Center Antananarivo Madagascar., Rakotomalala ADP; Endocrinology Department Joseph Raseta Befelatanana University Hospital Center Antananarivo Madagascar., Andrianasolo RL; Endocrinology Department Joseph Raseta Befelatanana University Hospital Center Antananarivo Madagascar.
Jazyk: angličtina
Zdroj: Clinical case reports [Clin Case Rep] 2023 Sep 04; Vol. 11 (9), pp. e7867. Date of Electronic Publication: 2023 Sep 04 (Print Publication: 2023).
DOI: 10.1002/ccr3.7867
Abstrakt: Key Clinical Message: The main type of urinary tract infection in hospitalized diabetics in Antananarivo is acute pyelonephritis; Escherichia coli is the most isolated uropathogen; imipenem, amikacin, fosfomycin and ceftriaxone are the major antibiotics for which Escherichia coli retain good sensitivity; Type 2 diabetes is predictive factor for infection by multidrug resistant bacteria.
Abstract: This study aimed to describe the epidemiological-clinical profiles of diabetics hospitalized for bacterial urinary tract infections in the Endocrinology Department of Befelatanana Hospital, to identify the main bacteria responsible, their antibiotic sensitivity profile and the factors associated with multidrug-resistant bacterial infection. A cross-sectional study was conducted between March 2017 and March 2020 involving all diabetics hospitalized for documented community-acquired bacterial urinary tract infection during this period. The hospital prevalence of urinary tract infections was 4.64%. The mean age of the patients was 59.06 ± 14.26 years and the sex ratio was 0.15. The main sign was fever (55.76%). The main clinical form was uncomplicated acute pyelonephritis (38.46%). Fifty-seven bacterial uropathogens were isolated. The most frequent was Escherichia coli (77.19%). Escherichia coli was sensitive to ertapenem and nitrofurantoin in 100% of cases, to Amikacin in 97.5% of cases, to Fosfomycin in 94.4% of cases and to Ceftriaxone in 80.65% of cases. Thirteen patients were infected with multidrug-resistant bacteria, all of them are extended-spectrum beta-lactamase-producing Enterobacteriaceae. Only the type of diabetes was associated with multidrug-resistant bacteria infection. The epidemiological-clinical and biological characteristics of urinary tract infections in our diabetics are similar to those reported in the literature. Compliance with the rules of proper antibiotic use is imperative to limit the emergence and spread of multidrug-resistant bacteria.
Competing Interests: The authors have declared that they have no competing interest.
(© 2023 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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