Evaluation of the effect of pitavastatin on motor deficit and functional recovery in sciatic nerve injury: A CatWalk study.

Autor:	Mansız-Kaplan B; Department of Ergotherapy, Ankara Medipol University, School of Health Sciences, Ankara, Türkiye., Kotanoğlu MS; Department of Anesthesiology and Reanimation, University of Health Sciences, Ankara Training and Research Hospital, Ankara, Türkiye., Gürsoy K; Department of Plastic Reconstructive and Aesthetic Surgery, University of Health Sciences, Ankara Training and Research Hospital, Ankara, Türkiye., Vural S; Department of Physical Medicine and Rehabilitation, University of Health Sciences, Ankara Training and Research Hospital, Ankara, Türkiye., Koca G; Department of Nuclear Medicine, University of Health Sciences, Ankara Training and Research Hospital, Ankara, Türkiye., Nacır B; Department of Physical Medicine and Rehabilitation, University of Health Sciences, Ankara Training and Research Hospital, Ankara, Türkiye., Yumuşak N; Department of Pathology, Harran University Faculty of Veterinary Medicine, Urfa, Türkiye., Kara H; Department of Pharmacology, Yıldırım Beyazıt University Faculty of Medicine, Ankara, Türkiye., Yüksel S; Department of Biostatistics, Yıldırım Beyazıt University Faculty of Medicine, Ankara, Türkiye., Korkmaz M; Department of Nuclear Medicine, University of Health Sciences, Ankara Training and Research Hospital, Ankara, Türkiye.
Jazyk:	angličtina
Zdroj:	Turkish journal of physical medicine and rehabilitation [Turk J Phys Med Rehabil] 2023 Jun 11; Vol. 69 (3), pp. 334-343. Date of Electronic Publication: 2023 Jun 11 (Print Publication: 2023).
DOI:	10.5606/tftrd.2023.11002
Abstrakt:	Objectives: This study aims to investigate the electrophysiological, scintigraphic, and histopathological effects of pitavastatin and its impact on functional status in rats with sciatic nerve injury. Materials and Methods: A total of 30 Wistar albino rats were divided into three equal groups including 10 rats in each group: sham group (no injury), control group (nerve injury induced), and pitavastatin group (nerve injury induced and 2 mg/kg of pitavastatin administered orally once a day for 21 days). Before and at the end of intervention, quantitative gait analysis with the CatWalk system and sciatic nerve conduction studies were performed. After the intervention, the gastrocnemius muscle was scintigraphically evaluated, and the sciatic nerve was histopathologically examined. Results: There was no significant difference in the sciatic nerve conduction before the intervention and Day 21 among the groups (p>0.05). According to the quantitative gait analysis, there were significant differences in the control group in terms of the individual, static, dynamic, and coordination parameters (p<0.05). The histopathological examination revealed a significant difference in the total myelinated axon count and mean axon diameter among the groups (p<0.001). Conclusion: Pitavastatin is effective in nerve regeneration and motor function recovery in rats with sciatic nerve injury. Competing Interests: Conflict of Interest: The authors declared no conflicts of interest with respect to the authorship and/or publication of this article. (Copyright © 2023, Turkish Society of Physical Medicine and Rehabilitation.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu