Uncovering the neurological effects of West Nile virus during a record-breaking southern Spain outbreak in 2020-2021.

Autor:	Hiraldo JDG; Department of Neurology, University Hospital Virgen Macarena, Seville, Spain., Fuerte-Hortigón A; Department of Neurology, University Hospital Virgen Macarena, Seville, Spain. Electronic address: alejandro.fuerte.sspa@juntadeandalucia.es., Domínguez-Mayoral A; Department of Neurology, University Hospital Virgen Macarena, Seville, Spain., De la Rosa Riestra S; Unit of Infectious Diseases and Clinical Microbiology, University Hospital Virgen Macarena/Institute of Biomedicine of Seville (IBIS), Spain., Palacios-Baena ZR; Unit of Infectious Diseases and Clinical Microbiology, University Hospital Virgen Macarena/Institute of Biomedicine of Seville (IBIS), Spain., Fernández FS; Department of Neurology, University Hospital Virgen Macarena, Seville, Spain., Ruiz RL; Department of Neurology, University Hospital Virgen Macarena, Seville, Spain., Pascual-Vaca D; Department of Paediatric Neurology, University Hospital Virgen Macarena, Seville, Spain., de León CM; Department of Clinical Neurophysiology, University Hospital Virgen Macarena, Seville, Spain., Hurtado RJ; Department of Clinical Neurophysiology, University Hospital Virgen Macarena, Seville, Spain., Sanbonmatsu-Gámez S; Department of Microbiology, Hospital Virgen de las Nieves Hospital, Granada, Spain.
Jazyk:	angličtina
Zdroj:	Journal of neuroimmunology [J Neuroimmunol] 2023 Oct 15; Vol. 383, pp. 578179. Date of Electronic Publication: 2023 Aug 25.
DOI:	10.1016/j.jneuroim.2023.578179
Abstrakt:	The 2020-21 West Nile Virus (WNV) outbreak in Andalusia, Spain, was the largest reported in the country, with eight cases of West Nile Neuroinvasive Disease (WNND) diagnosed in a tertiary hospital. Diagnosis of WNND is based on detecting WNV RNA, viral isolation, or demonstrating a specific immune response against the virus, with additional tests used to support the diagnosis. Treatment remains supportive, with variable outcomes. The potential efficacy of plasma exchange (PLEX) in select cases raises the possibility of an autoimmune component secondary to infectious pathology of the central nervous system. The influence of climate change on the expansion of WNV into new regions is a significant concern. It is crucial for physicians practicing in high-risk areas to be knowledgeable about the disease for early prevention and effective control measures. Competing Interests: Declaration of Competing Interest The authors declare no conflicts of interest. (Copyright © 2023. Published by Elsevier B.V.)
Databáze:	MEDLINE
Externí odkaz:	Full Text from ScienceDirect