[Effect of High-Concentration Uric Acid on Nitric Oxide].

Autor:	Qin SY; School of Clinical Medicine,Jiamusi University,Jiamusi,Heilongjiang 154007,China., Lan RY; School of Public Health,Jiamusi University,Jiamusi,Heilongjiang 154007,China., Zeng J; School of Public Health,Jiamusi University,Jiamusi,Heilongjiang 154007,China., Bai X; School of Clinical Medicine,Jiamusi University,Jiamusi,Heilongjiang 154007,China.; Heilongjiang Provincial Key Laboratory of Gout Research,Jiamusi University,Jiamusi,Heilongjiang 154007,China., Wang JT; School of Clinical Medicine,Jiamusi University,Jiamusi,Heilongjiang 154007,China., Yin XL; School of Public Health,Jiamusi University,Jiamusi,Heilongjiang 154007,China.; Heilongjiang Provincial Key Laboratory of Gout Research,Jiamusi University,Jiamusi,Heilongjiang 154007,China., Qu RJ; School of Public Health,Jiamusi University,Jiamusi,Heilongjiang 154007,China., Qu MH; School of Public Health,Jiamusi University,Jiamusi,Heilongjiang 154007,China., Jiang H; School of Public Health,Jiamusi University,Jiamusi,Heilongjiang 154007,China., Li WL; School of Clinical Medicine,Jiamusi University,Jiamusi,Heilongjiang 154007,China., Pei SY; School of Basic Medicine,Jiamusi University,Jiamusi,Heilongjiang 154007,China., Hou ZL; School of Clinical Medicine,Jiamusi University,Jiamusi,Heilongjiang 154007,China., Guan BS; School of Public Health,Jiamusi University,Jiamusi,Heilongjiang 154007,China.; Heilongjiang Provincial Key Laboratory of Gout Research,Jiamusi University,Jiamusi,Heilongjiang 154007,China., Qiu HB; School of Public Health,Jiamusi University,Jiamusi,Heilongjiang 154007,China.; Heilongjiang Provincial Key Laboratory of Gout Research,Jiamusi University,Jiamusi,Heilongjiang 154007,China.
Jazyk:	čínština
Zdroj:	Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae [Zhongguo Yi Xue Ke Xue Yuan Xue Bao] 2023 Aug; Vol. 45 (4), pp. 666-671.
DOI:	10.3881/j.issn.1000-503X.15049
Abstrakt:	Uric acid (UA) is the final product of purine metabolism in human body,and its metabolic disorder will induce hyperuricemia (HUA).The occurrence and development of HUA are associated with a variety of pathological mechanisms such as oxidative stress injury,activation of inflammatory cytokines,and activation of renin-angiotensin-aldosterone system.These mechanisms directly or indirectly affect the bioavailability of endogenous nitric oxide (NO).The decrease in NO bioavailability is common in the diseases with high concentration of UA as an independent risk factor.In this review,we summarize the mechanisms by which high concentrations of UA affect the endogenous NO bioavailability,with a focus on the mechanisms of high-concentration UA in decreasing the synthesis and/or increasing the consumption of NO.This review aims to provide references for alleviating the multisystem symptoms and improving the prognosis of HUA,and lay a theoretical foundation for in-depth study of the correlations between HUA and other metabolic diseases.
Databáze:	MEDLINE
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