Are informants required to obtain valid ratings on the Positive and Negative Syndrome Scale (PANSS)?

Autor: Nielsen CM; Psychosis Research Unit, Aarhus University Hospital - Psychiatry, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Kølbæk P; Psychosis Research Unit, Aarhus University Hospital - Psychiatry, Aarhus, Denmark. perpet@rm.dk.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. perpet@rm.dk.; Department of Affective Disorders, Aarhus University Hospital - Psychiatry, Aarhus, Denmark. perpet@rm.dk., Dines D; Psychosis Research Unit, Aarhus University Hospital - Psychiatry, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Opler M; MedAvante-ProPhase Inc, New York, NY, USA.; Department of Psychiatry, New York University School of Medicine, New York, NY, USA., Correll CU; Division of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, NY, USA.; Department of Psychiatry and Molecular Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA.; Department of Child and Adolescent Psychiatry and Psychotherapy, Charite Universitätsmedizin, Berlin, Germany., Østergaard SD; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Affective Disorders, Aarhus University Hospital - Psychiatry, Aarhus, Denmark.
Jazyk: angličtina
Zdroj: Schizophrenia (Heidelberg, Germany) [Schizophrenia (Heidelb)] 2023 Aug 31; Vol. 9 (1), pp. 54. Date of Electronic Publication: 2023 Aug 31.
DOI: 10.1038/s41537-023-00378-5
Abstrakt: Ratings on the Positive and Negative Syndrome Scale (PANSS) are ideally based on both a patient interview and an informant questionnaire. In research and clinical settings, however, the informant questionnaire is often omitted. This study investigated the consequences of omitting informant information by comparing PANSS ratings of patients with schizophrenia (n = 49 patients, 77 ratings) conducted with and without informant information, respectively. Additionally, changes in symptom severity over time based on ratings with and without informant information were also compared for the full PANSS and the six-item version of the PANSS (PANSS-6). PANSS ratings including informant information were higher than those without, both at the total score and individual item level. Additionally, the full PANSS appeared less "responsive" to baseline-to-endpoint changes for ratings without informant information compared to ratings including informant information, while no differences were found for the PANSS-6.
(© 2023. Springer Nature Limited.)
Databáze: MEDLINE
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