The impact of the immune system on lung injury and regeneration in COPD.

Autor:	Kapellos TS; Comprehensive Pneumology Center, Institute of Lung Health and Immunity, Helmholtz Munich, Member of the German Center for Lung Research (DZL), Munich, Germany., Conlon TM; Comprehensive Pneumology Center, Institute of Lung Health and Immunity, Helmholtz Munich, Member of the German Center for Lung Research (DZL), Munich, Germany., Yildirim AÖ; Comprehensive Pneumology Center, Institute of Lung Health and Immunity, Helmholtz Munich, Member of the German Center for Lung Research (DZL), Munich, Germany.; Institute of Experimental Pneumology, University Hospital, Ludwig Maximilians University of Munich, Munich, Germany., Lehmann M; Comprehensive Pneumology Center, Institute of Lung Health and Immunity, Helmholtz Munich, Member of the German Center for Lung Research (DZL), Munich, Germany mareike.lehmann@uni-marburg.de.; Institute for Lung Research, Philipps University of Marburg, Universities of Giessen and Marburg Lung Center, Member of the German Center for Lung Research (DZL), Marburg, Germany.
Jazyk:	angličtina
Zdroj:	The European respiratory journal [Eur Respir J] 2023 Oct 12; Vol. 62 (4). Date of Electronic Publication: 2023 Oct 12 (Print Publication: 2023).
DOI:	10.1183/13993003.00589-2023
Abstrakt:	COPD is a devastating respiratory condition that manifests via persistent inflammation, emphysema development and small airway remodelling. Lung regeneration is defined as the ability of the lung to repair itself after injury by the proliferation and differentiation of progenitor cell populations, and becomes impaired in the COPD lung as a consequence of cell intrinsic epithelial stem cell defects and signals from the micro-environment. Although the loss of structural integrity and lung regenerative capacity are critical for disease progression, our understanding of the cellular players and molecular pathways that hamper regeneration in COPD remains limited. Intriguingly, despite being a key driver of COPD pathogenesis, the role of the immune system in regulating lung regenerative mechanisms is understudied. In this review, we summarise recent evidence on the contribution of immune cells to lung injury and regeneration. We focus on four main axes: 1) the mechanisms via which myeloid cells cause alveolar degradation; 2) the formation of tertiary lymphoid structures and the production of autoreactive antibodies; 3) the consequences of inefficient apoptotic cell removal; and 4) the effects of innate and adaptive immune cell signalling on alveolar epithelial proliferation and differentiation. We finally provide insight on how recent technological advances in omics technologies and human ex vivo lung models can delineate immune cell-epithelium cross-talk and expedite precision pro-regenerative approaches toward reprogramming the alveolar immune niche to treat COPD. Competing Interests: Conflict of interest: M. Lehmann reports fees for a podcast from Berlin-Chemie outside the submitted work. All other authors have no potential conflicts of interest to disclose. (Copyright ©The authors 2023. For reproduction rights and permissions contact permissions@ersnet.org.)
Databáze:	MEDLINE
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