[Immunomorphological aspects of post-traumatic subatrophy of the eyeball].

Autor:	Filatova IA; Helmholtz National Medical Research Center of Eye Diseases, Moscow, Russia., Mokhammad IM; Helmholtz National Medical Research Center of Eye Diseases, Moscow, Russia., Shemetov SA; Helmholtz National Medical Research Center of Eye Diseases, Moscow, Russia., Kondratyeva UP; Helmholtz National Medical Research Center of Eye Diseases, Moscow, Russia., Balatskaya NV; Helmholtz National Medical Research Center of Eye Diseases, Moscow, Russia., Denisyuk VO; AO Meditsina (Clinic of Academician Roitberg), Moscow, Russia.
Jazyk:	ruština
Zdroj:	Vestnik oftalmologii [Vestn Oftalmol] 2023; Vol. 139 (4), pp. 26-34.
DOI:	10.17116/oftalma202313904126
Abstrakt:	Purpose: The study attempts to characterize immunomorphological disorders at different degrees of post-traumatic subatrophy of the eyeball. Material and Methods: The study included 123 patients with blind and unpromising eyes, eyeball subatrophy of various degrees, who were divided into three groups (1, 2 and 3) depending on the degree of eyeball subatrophy. Results: The greatest risk of autoimmune inflammation was observed in patients with degree I subatrophy. Contusion injury of the eye was proven to not exclude the course of post-traumatic autoimmune uveitis. The development of post-traumatic subatrophic process is associated with activation of systemic organ-specific immunity, shift of balance in main regulatory subpopulations. Conclusion: The study showed that the most severe clinical course of chronic post-traumatic uveitis is observed in patients as a result of penetrating trauma to the eyeball. The contusion nature of such ocular injury does not exclude the development of autoimmune inflammation.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu