Standardization of canine meningioma grading: Validation of new guidelines for reproducible histopathologic criteria.

Autor: Belluco S; Université de Lyon, VetAgro Sup, ICE UPSP 2016.A104, Axe Cancérologie, Marcy l'Etoile, Lyon, France., Marano G; Department of Biomedical and Clinical Sciences 'L. Sacco', University of Milan, Milan, Italy., Lurier T; INRAE, VetAgro Sup, UMR EPIA, Université Clermont Auvergne, Saint-Genès-Champanelle, France.; INRAE, VetAgro Sup, UMR EPIA, Université de Lyon, Lyon, France., Avallone G; Dipartimento di Scienze Mediche Veterinarie, Università di Bologna, Bologna, Italy., Brachelente C; Dipartimento di Medicina Veterinaria, Università degli Studi di Perugia, Perugia, Italy., Di Palma S; IDEXX Laboratories, Wetherby, UK., Rasotto R; Diagnostic Pathology, Dick White Referrals, Station Farm, Cambridgeshire, UK., Baiker K; Department of Veterinary Clinical Sciences, Jockey Club College of Veterinary Medicine and Science, City University of Hong Kong, Kowloon, Hong Kong., Beineke A; Stiftung Tierärztliche Hochschule Hannover, Institut für Pathologie, Hannover, Germany., Oevermann A; Division of Neurological Sciences, Vetsuisse Faculty, University of Bern, Bern, Switzerland., Seehusen F; Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland., de Sant'Ana FJF; Laboratório de Diagnóstico Patológico Veterinário, Universidade de Brasília, Brasília, Brazil., Boracchi P; Department of Biomedical and Clinical Sciences 'L. Sacco', University of Milan, Milan, Italy., Pumarola M; Dept Medicina i Cirurgia, Animals, Facultat de Veterinària, Barcelona, Spain., Mandara MT; Laboratorio di Neuropatologia, Dip. di Medicina Veterinaria, Università degli Studi di Perugia, Perugia, Italy.
Jazyk: angličtina
Zdroj: Veterinary and comparative oncology [Vet Comp Oncol] 2023 Dec; Vol. 21 (4), pp. 685-699. Date of Electronic Publication: 2023 Aug 27.
DOI: 10.1111/vco.12932
Abstrakt: Canine meningiomas are currently graded using the human grading system. Recently published guidelines have adapted the human grading system for use in dogs. The goal of this study was to validate the new guidelines for canine meningiomas. To evaluate the inter-observer agreement, 5 veterinary surgical pathologists graded 158 canine meningiomas following the human grading system alone or with the new guidelines. The inter-observer agreement for histologic grade and each of the grading criteria (mitotic grade, invasion, spontaneous necrosis, macronucleoli, small cells, hypercellularity, pattern loss and anaplasia) was evaluated using the Fleiss kappa index. The diagnostic accuracy (sensitivity and specificity) was assessed by comparing the diagnoses obtained with the 2 grading systems with a consensus grade (considered the reference classification). The consensus histologic grade was obtained by agreement between 4 experienced veterinary neuropathologists following the guidelines. Compared with the human grading alone, the canine-specific guidelines increased the inter-observer agreement for: histologic grade (κ = 0.52); invasion (κ = 0.67); necrosis (κ = 0.62); small cells (κ = 0.36); pattern loss (κ = 0.49) and anaplasia (κ = 0.55). Mitotic grade agreement remained substantial (κ = 0.63). The guidelines improved the sensitivity in identifying grade 1 (95.6%) and the specificity in identifying grade 2 (96.2%) meningiomas. In conclusion, the new grading guidelines for canine meningiomas are associated with an overall improvement in the inter-observer agreement and higher diagnostic accuracy in diagnosing grade 1 and grade 2 meningiomas.
(© 2023 The Authors. Veterinary and Comparative Oncology published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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