Significance of lipids, lipoproteins, and apolipoproteins during the first 14-16 months of life.

Autor:	Taageby Nielsen S; Department of Clinical Biochemistry, Copenhagen University Hospital-Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark., Mohr Lytsen R; Department of Clinical Biochemistry, Copenhagen University Hospital-Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark., Strandkjær N; Department of Cardiology, Copenhagen University Hospital-Herlev-Gentofte Hospital, Denmark., Juul Rasmussen I; Department of Clinical Biochemistry, Copenhagen University Hospital-Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark.; Department of Clinical Biochemistry, Copenhagen University Hospital-Herlev-Gentofte Hospital, Denmark., Sillesen AS; Department of Cardiology, Copenhagen University Hospital-Herlev-Gentofte Hospital, Denmark., Vøgg ROB; Department of Cardiology, Copenhagen University Hospital-Herlev-Gentofte Hospital, Denmark., Axelsson Raja A; Department of Cardiology, Copenhagen University Hospital-Rigshospitalet, Denmark., Nordestgaard BG; Department of Clinical Biochemistry, Copenhagen University Hospital-Herlev-Gentofte Hospital, Denmark.; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, Denmark., Kamstrup PR; Department of Clinical Biochemistry, Copenhagen University Hospital-Herlev-Gentofte Hospital, Denmark., Iversen K; Department of Cardiology, Copenhagen University Hospital-Herlev-Gentofte Hospital, Denmark.; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, Denmark., Bundgaard H; Department of Cardiology, Copenhagen University Hospital-Rigshospitalet, Denmark.; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, Denmark., Tybjærg-Hansen A; Department of Clinical Biochemistry, Copenhagen University Hospital-Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, Denmark., Frikke-Schmidt R; Department of Clinical Biochemistry, Copenhagen University Hospital-Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, Denmark.
Jazyk:	angličtina
Zdroj:	European heart journal [Eur Heart J] 2023 Nov 07; Vol. 44 (42), pp. 4408-4418.
DOI:	10.1093/eurheartj/ehad547
Abstrakt:	Background and Aims: The aims of this study were to investigate lipid parameters during the first 14-16 months of life, to identify influential factors, and to test whether high concentrations at birth predict high concentrations at 2- and 14-16 months. Methods: The Copenhagen Baby Heart Study, including 13,354 umbilical cord blood samples and parallel venous blood samples from children and parents at birth (n = 444), 2 months (n = 364), and 14-16 months (n = 168), was used. Results: Concentrations of lipids, lipoproteins, and apolipoproteins in umbilical cord blood samples correlated highly with venous blood samples from newborns. Concentrations of low-density lipoprotein (LDL) cholesterol, non-high-density lipoprotein (HDL) cholesterol, apolipoprotein B, and lipoprotein(a) increased stepwise from birth to 2 months to 14-16 months. Linear mixed models showed that concentrations of LDL cholesterol, non-HDL cholesterol, and lipoprotein(a) above the 80th percentile at birth were associated with significantly higher concentrations at 2 and 14-16 months. Finally, lipid concentrations differed according to sex, gestational age, birth weight, breastfeeding, and parental lipid concentrations. Conclusions: Lipid parameters changed during the first 14-16 months of life, and sex, gestational age, birth weight, breastfeeding, and high parental concentrations influenced concentrations. Children with high concentrations of atherogenic lipid traits at birth had higher concentrations at 2 and 14-16 months. These findings increase our knowledge of how lipid traits develop over the first 14-16 months of life and may help in deciding the optimal child age for universal familial hypercholesterolaemia screening. (© The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology.)
Databáze:	MEDLINE
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