Neonatal cortical activity organizes into transient network states that are affected by vigilance states and brain injury.

Autor: Khazaei M; Department of Neurosciences, Imaging and Clinical Sciences, University 'Gabriele d'Annunzio' of Chieti-Pescara, ITAB building, 3rd floor, room 314, Chieti, Via dei Vestini, Italy. Electronic address: mohammad.khazaei@unich.it., Raeisi K; Department of Neurosciences, Imaging and Clinical Sciences, University 'Gabriele d'Annunzio' of Chieti-Pescara, ITAB building, 3rd floor, room 314, Chieti, Via dei Vestini, Italy., Vanhatalo S; BABA center, Pediatric Research Center, Departments of Clinical Neurophysiology and Physiology, Children's Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland., Zappasodi F; Department of Neurosciences, Imaging and Clinical Sciences, University 'Gabriele d'Annunzio' of Chieti-Pescara, ITAB building, 3rd floor, room 314, Chieti, Via dei Vestini, Italy; Institute for Advanced Biomedical Technologies, University 'Gabriele d'Annunzio' of Chieti-Pescara, Chieti, Italy., Comani S; Department of Neurosciences, Imaging and Clinical Sciences, University 'Gabriele d'Annunzio' of Chieti-Pescara, ITAB building, 3rd floor, room 314, Chieti, Via dei Vestini, Italy; Behavioral Imaging and Neural Dynamics Center, University 'Gabriele d'Annunzio' of Chieti-Pescara, Chieti, Italy., Tokariev A; BABA center, Pediatric Research Center, Departments of Clinical Neurophysiology and Physiology, Children's Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Jazyk: angličtina
Zdroj: NeuroImage [Neuroimage] 2023 Oct 01; Vol. 279, pp. 120342. Date of Electronic Publication: 2023 Aug 22.
DOI: 10.1016/j.neuroimage.2023.120342
Abstrakt: Early neurodevelopment is critically dependent on the structure and dynamics of spontaneous neuronal activity; however, the natural organization of newborn cortical networks is poorly understood. Recent adult studies suggest that spontaneous cortical activity exhibits discrete network states with physiological correlates. Here, we studied newborn cortical activity during sleep using hidden Markov modeling to determine the presence of such discrete neonatal cortical states (NCS) in 107 newborn infants, with 47 of them presenting with a perinatal brain injury. Our results show that neonatal cortical activity organizes into four discrete NCSs that are present in both cardinal sleep states of a newborn infant, active and quiet sleep, respectively. These NCSs exhibit state-specific spectral and functional network characteristics. The sleep states exhibit different NCS dynamics, with quiet sleep presenting higher fronto-temporal activity and a stronger brain-wide neuronal coupling. Brain injury was associated with prolonged lifetimes of the transient NCSs, suggesting lowered dynamics, or flexibility, in the cortical networks. Taken together, the findings suggest that spontaneously occurring transient network states are already present at birth, with significant physiological and pathological correlates; this NCS analysis framework can be fully automatized, and it holds promise for offering an objective, global level measure of early brain function for benchmarking neurodevelopmental or clinical research.
Competing Interests: Declaration of Competing Interest No conflict of interest exists. All authors approve the submission.
(Copyright © 2023. Published by Elsevier Inc.)
Databáze: MEDLINE
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