Self-perception of natural outcome, appearance, and emotional well-being after OnabotulinumtoxinA treatment for upper facial lines: Post hoc analysis across age and gender.
Autor: | Dayan S; Denova Research, Chicago, Illinois, USA., Ogilvie P; Skin Concept, Munich, Germany., Boyd C; BOYD, Birmingham, Michigan, USA., De Boulle K; Aalst Dermatology Clinic, Aalst, Belgium., Cavallini M; Unit of Dermatology and Dermatosurgery, Centro Diagnostico Italiano, Milan, Italy., Garcia JK; Allergan Aesthetics, an AbbVie Company, Irvine, California, USA., Musumeci M; Allergan Aesthetics, an AbbVie Company, Rome, Italy. |
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Jazyk: | angličtina |
Zdroj: | Journal of cosmetic dermatology [J Cosmet Dermatol] 2024 Jan; Vol. 23 (1), pp. 107-116. Date of Electronic Publication: 2023 Aug 24. |
DOI: | 10.1111/jocd.15947 |
Abstrakt: | Background: OnabotulinumtoxinA (onabotA) is indicated for upper facial lines (UFL). Fear of unnatural-looking outcomes is a frequently reported treatment barrier. Aims: Examine patient-reported outcomes (PROs) after onabotA treatment for UFL. Methods: A post hoc analysis was conducted on two 12-month pivotal studies of onabotA for forehead and glabellar lines (20 U each), with/without treatment of crow's feet lines (±24 U). This analysis used PROs from the Facial Line Satisfaction Questionnaire: Items 4 (natural look), 5 (treatment effect), 11 (met expectations), and Impact Domain (appearance and psychological impact). The analysis included 458 neurotoxin-naive adults achieving a ≥2-grade improvement in forehead line (FHL) severity on the Facial Wrinkle Scale at Day 30 (primary endpoint). [Corrections made on 28 December 2023, after first online publication: 'UFL' in the previous sentence has been corrected to 'forehead line (FHL)' in this version.] Data were further stratified into millennials and men. Results: At Day 30, 90.5% of all participants, 94.6% of millennials, and 85.7% of men were satisfied with receiving a natural look. Millennials had higher odds of being satisfied with natural outcomes at Day 30. This measure remained > 80% for all groups throughout the 12 months. Additionally, ≥80% were satisfied with the treatment effect, and >90% reported results met expectations. At Day 30, ≥50% reported positive impacts on self-perceived appearance and psychological well-being, but millennials had higher, and men had lower odds of reporting these improvements. Conclusions: Participants achieving a ≥2-grade improvement in FHL severity after onabotA reported high satisfaction with natural outcomes and the treatment effect, with improved self-perceived appearance and psychological well-being. [Corrections made on 28 December 2023, after first online publication: 'UFL' in the previous sentence has been corrected to 'FHL' in this version.] These results may help aesthetic providers and patients address fears regarding unnatural results with onabotA. (© 2023 AbbVie Inc. Journal of Cosmetic Dermatology published by Wiley Periodicals LLC.) |
Databáze: | MEDLINE |
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