Scedosporium species and Lomentospora prolificans fungaemia is uniformly fatal in patients with haematological malignancy.

Autor: Stewart AG; Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Royal Brisbane and Women's Hospital Campus, Brisbane, Queensland, Australia.; Department of Infectious Diseases, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.; Central Microbiology, Pathology Queensland, Brisbane, Queensland, Australia., Heney C; Central Microbiology, Pathology Queensland, Brisbane, Queensland, Australia., Paterson DL; Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Royal Brisbane and Women's Hospital Campus, Brisbane, Queensland, Australia.; Department of Infectious Diseases, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia., Harris PNA; Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Royal Brisbane and Women's Hospital Campus, Brisbane, Queensland, Australia.; Central Microbiology, Pathology Queensland, Brisbane, Queensland, Australia., Edwards F; Queensland University of Technology, Brisbane, Queensland, Australia., Laupland KB; Queensland University of Technology, Brisbane, Queensland, Australia.; Department of Intensive Care Services, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.
Jazyk: angličtina
Zdroj: Internal medicine journal [Intern Med J] 2023 Aug; Vol. 53 (8), pp. 1489-1491.
DOI: 10.1111/imj.16198
Abstrakt: Scedosporium and Lomentospora species are environmental moulds that are virulent in immunocompromised hosts and rarely cause bloodstream infection (BSI). Patients with Scedosporium and Lomentospora species BSI were identified by the state public laboratory service in Queensland, Australia, over a 20-year period. Twenty-two incident episodes occurred among 21 residents; one patient had a second episode 321 days following the first. Of these, 18 were Lomentospora prolificans, three were Scedosporium apiospermum complex and one was a nonspeciated Scedosporium species. Seventeen (81%) patients died during their index admission, and all-cause mortality at 30, 90 and 365 days was 73%, 82% and 91% respectively. All 20 patients with haematological malignancy died within 365 days of follow-up with a median time to death of 9 days (interquartile range, 6-20 days) following diagnoses of BSI.
(© 2023 Royal Australasian College of Physicians.)
Databáze: MEDLINE
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