Durable Anti-Vi IgG and IgA Antibody Responses in 15-Month-Old Children Vaccinated With Typhoid Conjugate Vaccine in Burkina Faso.

Autor: Ouedraogo A; Groupe de Recherche Action en Santé, Ouagadougou, Burkina Faso., Diarra A; Groupe de Recherche Action en Santé, Ouagadougou, Burkina Faso., Nébié I; Groupe de Recherche Action en Santé, Ouagadougou, Burkina Faso., Barry N; Groupe de Recherche Action en Santé, Ouagadougou, Burkina Faso., Kabore JM; Groupe de Recherche Action en Santé, Ouagadougou, Burkina Faso., Tiono AB; Groupe de Recherche Action en Santé, Ouagadougou, Burkina Faso., Datta S; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA., Liang Y; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.; Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA., Mayo I; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA., Oshinsky JJ; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA., Tracy JK; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA., Girmay T; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA., Pasetti MF; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA., Jamka LP; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA., Neuzil KM; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA., Sirima SB; Groupe de Recherche Action en Santé, Ouagadougou, Burkina Faso., Laurens MB; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Jazyk: angličtina
Zdroj: Journal of the Pediatric Infectious Diseases Society [J Pediatric Infect Dis Soc] 2023 Sep 27; Vol. 12 (9), pp. 513-518.
DOI: 10.1093/jpids/piad058
Abstrakt: We assessed anti-Vi IgG/IgA responses to typhoid conjugate vaccine (TCV) in children enrolled in a double-blind randomized controlled, phase 2 trial in Burkina Faso. Anti-Vi IgG seroconversion and anti-Vi IgA titers were higher in TCV than control recipients at 30-35 months post-vaccination. TCV induces durable immunity in Burkinabe children vaccinated at 15 months.
(© The Author(s) 2023. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society.)
Databáze: MEDLINE
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