Serum Electrolyte and Metabolic Changes During Conditioning of Autologous Hematopoietic Stem Cell Transplantation in Patients with Autoimmune Diseases: A Prospective Study in a Single Institution.

Autor:	Méndez-Laureano BJ; Laboratorios Ruiz, SYNLAB, Puebla, México.; Universidad Popular Autónoma del Estado de Puebla, Puebla, México., Gallardo-Pérez MM; Universidad Popular Autónoma del Estado de Puebla, Puebla, México.; Centro de Hematología y Medicina Interna, Clínica Ruiz, Puebla, México., Minutti-Zanella C; Laboratorios Ruiz, SYNLAB, Puebla, México.; Universidad Popular Autónoma del Estado de Puebla, Puebla, México., Ruiz-Argüelles GJ; Universidad Popular Autónoma del Estado de Puebla, Puebla, México.; Centro de Hematología y Medicina Interna, Clínica Ruiz, Puebla, México.
Jazyk:	angličtina
Zdroj:	Hematology/oncology and stem cell therapy [Hematol Oncol Stem Cell Ther] 2023 Jul 20; Vol. 17 (1), pp. 29-36. Date of Electronic Publication: 2023 Jul 20.
DOI:	10.56875/2589-0646.1106
Abstrakt:	Background and Objectives: A hematopoietic stem cell transplant (HSCT) includes a conditioning regimen which may cause unwanted metabolic changes. We analyzed the changes in electrolytes, glucose, urea, and glomerular filtration rate in patients with multiple sclerosis (MS) who underwent an autologous HSCT employing the "Mexican method." Patients and Methods: Serum and urinary electrolytes, blood glucose, creatinine, uric acid, and estimated glomerular filtration rate (eGFR) were prospectively assessed on days -11, -9, and 0 in a group of 75 patients with MS receiving an autologous HSCT employing the "Mexican method," which includes high doses of both cyclophosphamide (Cy, 200 mg/kg) and rituximab (1000 mg). Results: The median age of the patients was 46 years, with a range of 20-65. Baseline data were defined at day -11 of the HSCT. There were significant changes in serum and urinary electrolytes, which diminished substantially after the delivery of high-dose Cy; 12 patients (16%) developed hyponatremia and 2 had hyponatremia-induced seizures, which resulted in hospital admissions. A comparison of baseline blood metabolites with those obtained after the full Cy dosage (day 0) revealed a significant increase in blood glucose and uric acid levels with an associated decrease in serum calcium, sodium, and potassium levels. The salient findings were drug-induced hyponatremia and hyperglycemia. Conclusion: Significant changes in serum electrolytes, blood glucose, creatinine, uric acid, and estimated glomerular filtration rate (eGFR) were observed in patients given autologous HSCT for MS employing high-dose Cy. Some of these changes may have clinical consequences, mainly those derived from iatrogenic hyponatremia. No evidence of damage to renal function was observed at day 0.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu