| Autor: |
Ureta-Velasco N; Department of Neonatology, 12 de Octubre University Hospital, 28041 Madrid, Spain.; Research Institute i+12, 12 de Octubre University Hospital, 28041 Madrid, Spain.; Faculty of Medicine, Complutense University of Madrid, 28040 Madrid, Spain., Montealegre-Pomar A; Epidemiología Clínica, Pontificia Universidad Javeriana, Hospital Universitario San Ignacio, Bogotá 110231, Colombia., Keller K; Research Institute i+12, 12 de Octubre University Hospital, 28041 Madrid, Spain.; 'Aladina-MGU'-Regional Human Milk Bank, 12 de Octubre University Hospital, 28041 Madrid, Spain., Escuder-Vieco D; Research Institute i+12, 12 de Octubre University Hospital, 28041 Madrid, Spain.; 'Aladina-MGU'-Regional Human Milk Bank, 12 de Octubre University Hospital, 28041 Madrid, Spain., Fontecha J; Food Lipid Biomarkers and Health Group, Institute of Food Science Research (CIAL), CSIC-UAM, 28049 Madrid, Spain., Calvo MV; Food Lipid Biomarkers and Health Group, Institute of Food Science Research (CIAL), CSIC-UAM, 28049 Madrid, Spain., Megino-Tello J; Food Lipid Biomarkers and Health Group, Institute of Food Science Research (CIAL), CSIC-UAM, 28049 Madrid, Spain., Serrano JCE; Department of Experimental Medicine, Faculty of Medicine, University of Lleida, 25008 Lleida, Spain., García-Lara NR; Department of Neonatology, 12 de Octubre University Hospital, 28041 Madrid, Spain.; Research Institute i+12, 12 de Octubre University Hospital, 28041 Madrid, Spain.; 'Aladina-MGU'-Regional Human Milk Bank, 12 de Octubre University Hospital, 28041 Madrid, Spain., Pallás-Alonso CR; Department of Neonatology, 12 de Octubre University Hospital, 28041 Madrid, Spain.; Research Institute i+12, 12 de Octubre University Hospital, 28041 Madrid, Spain.; Faculty of Medicine, Complutense University of Madrid, 28040 Madrid, Spain. |
| Abstrakt: |
The influence of the diet and nutritional status of milk donors on the nutritional composition of donor human milk (DHM) is unknown. The present study aimed to determine the nutritional profile of DHM and the associations between donors' dietary intake and nutritional status and the micronutrient and lipid composition in DHM. For this purpose, 113 donors completed a food frequency questionnaire, provided a five-day weighed dietary record, and collected milk for five consecutive days. Nutrient determinations in donors' erythrocytes, plasma, urine, and milk were performed. Multiple linear regressions were conducted for the evaluation of the associations. We highlight the following results: DHM docosahexaenoic acid (DHA) was positively associated with donors' plasma DHA content and donors' DHA intake (R 2 0.45, p < 0.001). For every 1 g/day DHA intake, an increase of 0.38% in DHA content and 0.78% in total omega-3 content was observed in DHM (R 2 0.29, p < 0.001). DHM saturated fatty acids were positively associated with erythrocyte dimethyl acetals, plasma stearic acid, trans fatty acids intake, and breastfeeding duration and negatively associated with erythrocyte margaroleic acid (R 2 0.34, p < 0.01). DHM cholecalciferol was associated with plasma cholecalciferol levels and dairy intake (R 2 0.57, p < 0.01). Other weaker associations were found for free thiamin, free riboflavin, pyridoxal, dehydroascorbic acid, and the lipid profile in DHM. In conclusion, the diet and nutritional status of donors influence the fatty acid profile and micronutrient content of DHM. |
