Muscle quality and not quantity as a predictor of survival in head and neck squamous cell carcinoma.

Autor: Roberti E; Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, ASST Spedali Civili, Brescia, Italy; University of Brescia Residency School in Anesthesiology and Intensive Care Medicine, University of Brescia, Brescia, Italy., Merlano M; Department of Medical Oncology, S Croce and Carle Teaching Hospital, Cuneo, Italy., Ravanelli M; Department of Radiology, University of Brescia, Italy., Alberti A; Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, ASST Spedali Civili, Brescia, Italy., Esposito A; Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, ASST Spedali Civili, Brescia, Italy., Gili R; UO Oncologia Medica 2, IRCCS Ospedale Policlinico San Martino, Genova, Italy; Department of Internal Medicine and Medical Specialties (DiMI), School of Medicine, University of Genoa, Genoa, Italy., Spinazzé S; Medical Oncology Unit, Ospedale U. Parini, Viale Ginevra 3, 11100 Aosta, Italy., Baré C; Medical Oncology Unit, Ospedale U. Parini, Viale Ginevra 3, 11100 Aosta, Italy., Jocollé G; Medical Oncology Unit, Ospedale U. Parini, Viale Ginevra 3, 11100 Aosta, Italy., Benasso M; Department of Oncology, San Paolo Hospital, Savona, Italy., Bertolotti F; Department of Oncology, San Paolo Hospital, Savona, Italy., Vecchio S; UO Oncologia Medica 2, IRCCS Ospedale Policlinico San Martino, Genova, Italy., Bacigalupo A; UO Oncologia Medica 2, IRCCS Ospedale Policlinico San Martino, Genova, Italy., Licitra L; Fondazione IRCCS Istituto Nazionale dei Tumori & University of Milan, Milan, Italy; Department of Oncology and Hemato-Oncology, University of Milan, 20122 Milan, Italy., Denaro N; Medical Oncology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy., Damico M; Unit of Medical Oncology, Galliera Hospital, Genoa, Italy., Lorini L; IRCCS Humanitas Research Hospital, via Manzoni 56, 20089 Rozzano, Milan, Italy., Gurizzan C; Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, ASST Spedali Civili, Brescia, Italy., Alfieri S; Department of Oncology and Hemato-Oncology, University of Milan, 20122 Milan, Italy., Bossi P; IRCCS Humanitas Research Hospital, via Manzoni 56, 20089 Rozzano, Milan, Italy; Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20072 Pieve Emanuele, Milan, Italy. Electronic address: paolo.bossi@hunimed.eu.
Jazyk: angličtina
Zdroj: Oral oncology [Oral Oncol] 2023 Oct; Vol. 145, pp. 106540. Date of Electronic Publication: 2023 Aug 09.
DOI: 10.1016/j.oraloncology.2023.106540
Abstrakt: Background: Sarcopenia is frequent in head and neck squamous cell carcinoma (HNSCC), as a consequence of malnutrition related to risk factors or tumoral mass. Treatment is associated with toxicities that lead to reduced calories intake and muscle mass wasting. Sarcopenia has been negatively associated with tumor control and survival outcomes.
Purpose: Our aim is to evaluate the prognostic impact of sarcopenia on overall survival (OS) and progression free survival (PFS) in HNSCC patients undergoing chemoradiation therapy within a prospective clinical trial of chemoradiation vs induction chemotherapy followed by radiation and cetuximab (INTERCEPTOR).
Materials and Methods: On baseline CT or MRI, we investigated the association between OS and PFS with radiological markers of sarcopenia, measured at the third cervical vertebra level. We studied paravertebral skeletal muscles area (cm 2 ), muscle density (HU), muscle index (cm 2 /m 2 ), and intermuscular adipose tissue (IMAT) area (cm 2 ).
Results: Imaging of 128 patients was evaluable. We found out that higher body mass index (BMI) was associated with better OS (p = 0.02), and PFS (p = 0.04). Skeletal muscle area (p = 0.02), and IMAT (p = 0.02) were negatively associated with PFS. IMAT was positively correlated with muscle area (Correlation coefficient 0.6, CI95% 0.47-0.7), and negatively associated with muscle density (Correlation coefficient -0.37, CI95% -0.53 - -0.18).
Conclusions: IMAT can be used as predictor of PFS in HNC patients undergoing chemoradiation therapy. The amount of intermuscular fat deposits induces alterations of muscle quality, without alterations of muscle quantity, influencing patients' prognosis.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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