[Acute hemorrhagic leukoencephalitis with a subacute onset].

Autor: Zakroyshchikova IV; Research center of Neurology, Moscow, Russia., Askarova LS; Research center of Neurology, Moscow, Russia., Bryukhov VV; Research center of Neurology, Moscow, Russia., Anufriev PL; Research center of Neurology, Moscow, Russia., Kozlova AO; Research center of Neurology, Moscow, Russia., Zakharova MN; Research center of Neurology, Moscow, Russia.
Jazyk: ruština
Zdroj: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova [Zh Nevrol Psikhiatr Im S S Korsakova] 2023; Vol. 123 (7. Vyp. 2), pp. 116-121.
DOI: 10.17116/jnevro2023123072116
Abstrakt: Acute hemorrhagic leukoencephalitis (AHLE), also called Hurst's encephalitis, is a rare demyelinating disease of the central nervous system characterized by rapid progression and acute inflammation of the white matter of the brain and spinal cord. AHLE is currently considered as a rare, most severe variant of acute disseminated encephalomyelitis. Clinically AHLE is characterized by a fulminant course with a rapid development of encephalopathy and multifocal neurological symptoms. AHLE is associated with high mortality rate that requires immediate and aggressive treatment initiation. This article describes a case of AHLE with an atypical course, a subacute form, which is extremely rarely described in the literature, with the progressive symptoms' development over several months. Due to delayed treatment initiation, unfortunately, a fatal outcome has been observed. Subsequent histological examination of the autopsy material confirmed the presence of a subacute form of AHLE in the patient.
Databáze: MEDLINE