Use of high flow nasal cannula oxygen therapy for patients infected with SARS-CoV-2 outside intensive care setting.
| Autor: | Tong CK; Department of Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong, China., Chan YH; Department of Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong, China., Leung CCD; Department of Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong, China., Kwok CT; Department of Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong, China., Ng LW; Department of Accident and Emergency, North Lantau Hospital, Hong Kong, China., Wong OF; Department of Accident and Emergency, North Lantau Hospital, Hong Kong, China., Yeung YC; Department of Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong, China., Tsang TY; Department of Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong, China., Chan NY; Department of Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong, China., Law CB; Department of Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong, China. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of thoracic disease [J Thorac Dis] 2023 Jul 31; Vol. 15 (7), pp. 3699-3707. Date of Electronic Publication: 2023 Jul 05. |
| DOI: | 10.21037/jtd-22-1507 |
| Abstrakt: | Background: In early 2022, there was a sudden surge of patients infected by the Omicron variant of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in Hong Kong (HK), resulting in 9,163 deaths as of 29 May 2022. Many of the local population had not been vaccinated before this wave. The number of patients who developed coronavirus disease 2019 (COVID-19) related respiratory failure outnumbered the capacity of intensive care unit (ICU) beds. Some of these patients had to be supported with high flow nasal cannula (HFNC) therapy outside ICU setting. HK was in crisis situation. The primary objective of this study is to assess the 28-day mortality of this group of patients. The secondary objective is to explore any predictors of non-survivors to help clinical decision-making in future crisis. Methods: This is a retrospective observational study of patients suffering from COVID-19 related respiratory failure who received HFNC therapy in general medical wards of two hospitals during the period of 17 Mar to 30 Apr 2022. Survival and risk factors were reviewed. Results: Forty-nine patients were recruited. Twenty-six patients (53%) survived at 28-day after initiation of HFNC support. Three clinical parameters were found to be significantly associated with mortality at 28-day: (I) SpO Conclusions: Use of HFNC outside ICU setting showed benefit to patients suffering from COVID-19 related acute hypoxemic respiratory failure (AHRF). Serial SF ratio monitoring at 48 and 72 hours after therapy initiation might serve as predictors of outcome and thus guide clinical decision-making for medical resource allocation in outbreak situation. Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://jtd.amegroups.com/article/view/10.21037/jtd-22-1507/coif). The authors have no conflicts of interest to declare. (2023 Journal of Thoracic Disease. All rights reserved.) |
| Databáze: | MEDLINE |
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