Beta-caryophyllene mitigates the cognitive impairment caused by repeated exposure to aspartame in rats: Putative role of BDNF-TrKB signaling pathway and acetylcholinesterase activity.

Autor: Rosa ÉVF; Program in Pharmacology, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil., Da Silveira AR; Program in Pharmacology, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil., Sari MHM; Program in Pharmaceutical Science, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil., Sampaio TB; Program in Pharmacology, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil., Dos Santos JT; Program in Pharmacology, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil., Müller SG; Program in Biological Sciences: Toxicological Biochemistry, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil., Fighera MR; Program in Biological Sciences: Toxicological Biochemistry, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil., Royes LFF; Program in Biological Sciences: Toxicological Biochemistry, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil., Nogueira CW; Program in Biological Sciences: Toxicological Biochemistry, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil., Oliveira MS; Program in Pharmacology, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil., Furian AF; Program in Pharmacology, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil; Program in Food Science and Technology, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil. Electronic address: ana.furian@ufsm.com.
Jazyk: angličtina
Zdroj: Behavioural brain research [Behav Brain Res] 2023 Sep 13; Vol. 453, pp. 114615. Date of Electronic Publication: 2023 Aug 07.
DOI: 10.1016/j.bbr.2023.114615
Abstrakt: Aspartame (ASP) is a common sweetener, but studies show it can harm the nervous system, causing learning and memory deficits. β-caryophyllene (BCP), a natural compound found in foods, including bread, coffee, alcoholic beverages, and spices, has already described as a neuroprotector agent. Remarkably, ASP and BCP are commonly consumed, including in the same meal. Therefore, considering that (a) the BCP displays plenty of beneficial effects; (b) the ASP toxicity; and (c) that they can be consumed in the same meal, this study sought to investigate if the BCP would mitigate the memory impairment induced by ASP in rats and investigate the involvement of the brain-derived neurotrophic factor (BDNF)/ tropomyosin receptor kinase B (TrKB) signaling pathway and acetylcholinesterase (AChE) activity. Young male Wistar rats received ASP (75 mg/kg; i.g.) and/or BCP (100 mg/kg; i.p.) once daily, for 14 days. At the end of the treatment, the animals were evaluated in the open field and object recognition tests. The cerebral cortex and hippocampus samples were collected for biochemical and molecular analyses. Results showed that the BCP effectively protected against the cognitive damage caused by ASP in short and long-term memories. In addition, BCP mitigated the increase in AChE activity caused by ASP. Molecular insights revealed augmented BDNF and TrKB levels in the hippocampus of rats treated with BCP, indicating greater activation of this pathway. In conclusion, BCP protected against ASP-induced memory impairment. AChE activity and the BDNF/TrkB signaling pathway seem to be potential targets of BCP modulatory role in this study.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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