The Level of Inflammatory Markers and Their Relationship with Fat Tissue Distribution in Children with Obesity and Type 2 Diabetes Mellitus.

Autor: Akalın Ertürk B; Health Sciences University, Dr Sami Ulus Obstetrics, Gynecology and Pediatrics Education And Research Hospital, Children's Health and Disease Health Implementation and Research Center, Ankara, Turkey., Gülbahar Ö; Gazi University Faculty of Medicine, Ankara, Turkey., Kaymak Şahap S; Ankara University Faculty of Medicine, Ankara, Turkey., Deveci Bulut TS; Department of Medical Biochemistry, Gazi University Faculty of Medicine, Ankara, Turkey., Çetinkaya S; Health Sciences University, Dr Sami Ulus Obstetrics, Gynecology and Pediatrics Education And Research Hospital, Children's Health and Disease Health Implementation and Research Center, Ankara, Turkey., Savaş Erdeve Ş; Health Sciences University, Dr Sami Ulus Obstetrics, Gynecology and Pediatrics Education And Research Hospital, Children's Health and Disease Health Implementation and Research Center, Ankara, Turkey.
Jazyk: angličtina
Zdroj: Turkish archives of pediatrics [Turk Arch Pediatr] 2023 Sep; Vol. 58 (5), pp. 485-493.
DOI: 10.5152/TurkArchPediatr.2023.22288
Abstrakt: Objective: This study aimed to determine the changes in proinflammatory and anti-inflam- matory markers in children aged 10-18, who were not diagnosed with type 2 diabetes mel- litus, were obese/overweight, and children with type 2 diabetes mellitus. In addition, we aimed to investigate whether these markers were associated with clinical and laboratory parame- ters, subcutaneous adipose tissue, preperitoneal adipose tissue, visceral adipose tissue, and hepatosteatosis.
Materials and Methods: Children between the ages of 10 and 18, obese/overweight, with type 2 diabetes mellitus, and with a normal body mass index were included. Fat tissue thick- ness was measured. Tumor necrosis factor-α, interleukin-1β, interleukin-6, interleukin-18, and interferon-γ as proinflammatory markers and transforming growth factor-β and interleukin-10 levels as anti-inflammatory markers were studied.
Results: Twenty-eight (31.8%) controls, 44 (50%) obese/overweight, and 16 (18.2%) patients with type 2 diabetes mellitus were included in our study. Age, sex, and puberty were similar between the groups. In the type 2 diabetes mellitus group, the subcutaneous fat tissue thick- ness was higher than that in the obese group, and the preperitoneal and visceral fat tissue thicknesses were similar to those in the obese group. Proinflammatory markers and interleu- kin-10 levels were similar in the obese/overweight, type 2 diabetes mellitus, and control groups. Transforming growth factor-β levels were significantly lower in the type 2 diabetes mellitus group than in the control group (P = .039). Transforming growth factor-β levels and other labo- ratory variables did not differ significantly in the type 2 diabetes mellitus group.
Conclusion: While there was no change in all markers in the obese/overweight group com- pared with the control group, proinflammatory markers in the type 2 diabetes mellitus group were similar to those in the obese/overweight and control groups, and transforming growth factor-β level, an anti-inflammatory marker, was lower in the type 2 diabetes mellitus group than in the control group.
Databáze: MEDLINE
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